- NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF
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The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal us
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(2010/04/30)
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- REACTION OF D-GALACTOSE PHENYLHYDRAZONE WITH NITROALKENES:SYNTHESIS OF PENTAHYDROXYPENTYLPYRAZOLES
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D-Galactose phenylhydrazone reacts with 1- and 2-substituted and 1,2-disubstituted nitroalkenes, with loss of the nitro group, to give moderate yields of 3-(D-galacto-pentitol-1-yl)-1-phenylpyrazoles variously substituted at positins 4, 5 and a mechanism is proposed.Acetylation of these products affords pentaacetates and periodate oxidation gave the corresponding 1-phenylpyrazole-3-carbaldehyde derivatives, some of which were oxidised to the carboxylic acids.U.v., i.r., and n.m.r. data confirm the proposed structures.
- Guillen, Manuel Gomez,Jiminez, Juan L. Conde
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