- Heterolytic (2 e) vs Homolytic (1 e) Oxidation Reactivity: N?H versus C?H Switch in the Oxidation of Lactams by Dioxirans
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Dioxiranes are powerful oxidants that can act via two different mechanisms: 1) homolytic (H abstraction and oxygen rebound) and 2) heterolytic (electrophilic oxidation). So far, it has been reported that the nature of the substrate dictates the reaction mode independently from the dioxirane employed. Herein, we report an unprecedented case in which the nature of the dioxirane rules the oxidation chemoselectivity. In particular, a switch from C?H to N?H oxidation is observed in the oxidation of lactams moving from dimethyl dioxirane (DDO) to methyl(trifluoromethyl)dioxirane (TFDO). A physical organic chemistry study, which combines the oxidation with two other dioxiranes methyl(fluoromethyl)dioxirane, MFDO, and methyl(difluoromethyl)dioxirane, DFDO, with computational studies, points to a diverse ability of the dioxiranes to either stabilize the homo or the heterolytic pathway.
- Annese, Cosimo,D'Accolti, Lucia,Fusco, Caterina,Licini, Giulia,Zonta, Cristiano
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supporting information
p. 259 - 262
(2017/01/17)
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- Synthesis of ω-nitro acids and ω-amino acids by ring cleavage of α- nitrocycloalkanones
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The reaction of various α-nitrocycloalkanones 1 with aqueous 0.05 M NaOH, at 80 °C, in the presence of cetyltrimethylammonium chloride (CTACl) as a cationic surfactant, produces ω-nitro acids 2 in good yields. Reduction of the latter with HCOONH4/Pd-C, in methanol, at 80 °C affords ω-amino acids 3. The synthesis of methyl 9-oxodecanoate (8) is also reported.
- Ballini, Roberto,Papa, Fabrizio,Abate, Corrado
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- The Conversion of Aliphatic Primary Alcohols to the Corresponding Carboxylic Acids Using Calcium Hypochlorite
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The reaction of aliphatic primary alcohols with calcium hypochlorite in the presence of hydrochloric acid and excess tert-butanol produces the corresponding carboxylic acids in good yields.
- Kabalka, George W.,Chatla, Narayana,Wadgaonkar, Prakash P.,Deshpande, Sunil M.
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p. 1617 - 1623
(2007/10/02)
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