- SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
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Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.
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Page/Page column 141-142
(2012/12/13)
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- Indole-sulfonamides as antitumor agents
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This invention provides certain indolinesulfonamide and substituted-indolesulfonamide derivatives of the formula wherein: R1 is C1-C6 alkyl;, R2 and R3 are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, and trifluoromethyl, provided that no more than one of R2 and R3 can be hydrogen;, and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these indolinesulfonamide and substituted-indolesulfonamide derivatives in combination with a carrier, excipient or diluent, as well as processes for preparing the compounds.
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