Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions
A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.
Zhang, Xitao,Feng, Xiujuan,Zhang, Haixia,Yamamoto, Yoshinori,Bao, Ming
supporting information
p. 5565 - 5570
(2019/10/22)
Mild, visible light-mediated decarboxylation of aryl carboxylic acids to access aryl radicals
Herein we present the first example of aryl radical formation via the visible light-mediated decarboxylation of aryl carboxylic acids using photoredox catalysis. This method constitutes a mild protocol for the decarboxylation of cheap and abundant aryl carboxylic acids and tolerates both electron-rich substrates and those lacking ortho-substitution. The in situ formation of an acyl hypobromite is proposed to prevent unproductive hydrogen atom abstraction and trapping of the intermediate aroyloxy radical, enabling mild decarboxylation.
Candish,Freitag,Gensch,Glorius
p. 3618 - 3622
(2017/07/11)
Organometallic compound and organic light emitting device including the same
Disclosed are an organometallic compound and an organic light emitting device comprising the same. The organometallic compound is represented by chemical formula 1. The organic light emitting device using the organometallic compound can have a low driving
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Paragraph 0304; 0314-0316
(2017/01/02)
Directed deprotonation-transmetalation as a route to substituted pyridines
matrix presented Regioselective C-4 deprotonation of 3-bromopyridine, followed by Li/Zn transmetalation and Pd-mediated coupling processes, provides a flexible entry to 4-substituted and 3,4-disubstituted pyridines. Application of a similar sequence to 2-
Karig, Gunter,Spencer, James A.,Gallagher, Timothy
p. 835 - 838
(2007/10/03)
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