- Synthesis method of cyromazine active compound with high yield
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The invention relates to a synthesis method of a cyromazine active compound with high yield, cyanuric chloride, cyclopropylamine and ammonia gas are used as raw materials, single toluene is used as a solvent to synthesize the cyromazine active compound, the purity is more than 98%, and the yield is as high as 93%. The method has the characteristics of simplicity in operation, high solvent utilization rate, high product yield, less environmental pollution and the like. The labor load of workers is reduced, the production cost is reduced, and the environmental pollution is reduced.
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Paragraph 0040-0044; 0048-0052; 0056-0060
(2021/05/29)
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- Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline-triazine derivatives
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A series of novel hybrid quinazoline-triazine derivatives was designed and synthesized from cyanuric chloride and anthranilic acid through sequential reactions, which contain different pharmacophores like quinazoline and substituted diaryl triazine (DATA)
- Modh, Rahul P.,De Clercq, Erik,Pannecouque, Christophe,Chikhalia, Kishor H.
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p. 100 - 108
(2014/03/21)
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- Synthesis of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids as potential antimalarial agents
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We report herein synthesis of a series of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids and evaluate their antimalarial activity against D6 and W2 strains of Plasmodium falciparum. To study the structure-activi
- Manohar, Sunny,Khan, Shabana I.,Rawat, Diwan S.
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experimental part
p. 124 - 136
(2012/06/01)
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- Selective NPY (Y5) antagonists (triazines)
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This invention is directed to triazine derivatives which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.
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Page column 17
(2010/01/30)
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- Influence of the hapten design on the development of a competitive ELISA for the determination of the antifouling agent Irgarol 1051 at trace levels
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Enzyme-linked immunosorbent assays (ELISAs) with a high detectability have been developed for determination of the antifouling agent Irgarol 1051. The features of the resulting assays have been rationalized by using molecular mechanic calculations (MM2+) to correlate the chemical structure of different immunizing haptens and the corresponding avidities of the obtained antisera. The ability of Irgarol 1051 to compete for the antibody binding sites with 11 horseradish peroxidase enzyme tracers, differing in the chemical structures of the hapten, has been investigated. The present paper demonstrates that high-quality antibodies and, therefore, immunoassays reaching very low detection limits could be predicted by molecular modeling studies of the analyte conformations and of the immunizing haptens' geometries, hydrogen-bonding capabilities, and electronic distributions. Two of the ELISAs obtained have been optimized to obtain reproducible immunoassays. The dynamic ranges of both assays are between 30 and 200 ng/L, and the limits of detection are ~16 ng/L. The reported immunoassays have been evaluated and validated by analyzing spiked and real seawater samples. Irgarol 1051 has been found to be present in two of the geographical locations analyzed at concentration levels dependent on the time of year. The analytical results obtained with these immunoassays have been validated by chromatographic methods.
- Ballesteros, Berta,Barcelo, Damia,Sanchez-Baeza, Francisco,Camps, Francisco,Marco, Maria-Pilar
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p. 4004 - 4014
(2007/10/03)
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- 2-Cyclopropylamino-4,6-diamino-s-triazine
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2-Cyclopropylamino-4,6-diamino-s-triazine and acid addition salts thereof for combatting developmental stages of insects.
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