A practical strategy for the synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines
Starting from commercially available 4-amino-2,6-dichloropyrimidine, a practical four steps synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines was developed. This strategy could introduce a diverse set of secondary amines and arylamines to displac
Li, Chaomin,Rosenau, Andrew
experimental part
p. 5888 - 5893
(2010/01/18)
Solid-phase synthesis of 2,4,6-triaminopyrimidines
Substituted pyrimidines are an important class of kinase inhibitors. We therefore developed a synthetic route suitable for the solid-phase synthesis of 2,4,6-triaminopyrimidines through displacement reactions on deactivated pyrimidines. Functionalising th
Guillier, Fabrice,Roussel, Patrick,Moser, Heinz,Kane, Peter,Bradley, Mark
p. 3450 - 3458
(2007/10/03)
THE SYNTHESIS AND AMINOLYSIS OF SOME 4-CHLORO-2-(SUBSTITUTED)THIOPYRIMIDINES
Some 2-methylthio,2-methylsulphinyl and 2-methylsulphonyl-4-chloropyrimidines have been prepared.In each case which was studied except one the chloride ion was that which was preferentially displaced by diethylamine.The pseudo first order rate constant of for each reaction was determined the results showing that oxidation of the 2-methylthio group greatly enhances the rate of displacement of the 4-chloro group.
Hurst, Derek, T.,Johnson, Matthew
p. 611 - 616
(2007/10/02)
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