Synthesis and molecular modeling studies of fullerene-5,6,7-trimethoxyindole-oligonucleotide conjugates as possible probes for study of photochemical reactions in DNA triple helices
The synthesis of novel functionalized fullerene derivatives containing DNA minor groove binders is reported. In order to construct sequence-specific probes for DNA photomodification, the compounds were attached to a triple helix forming oligonucleotide, and the formation of triplexes was monitored. The triplex formation was demonstrated, but the presence of fullerene moieties gives rise to a high degree of instability. Molecular modeling studies on these supramolecular structures provided useful information for the current study and for future developments.
Da Ros, Tatiana,Bergamin, Massimo,Vazquez, Ester,Spalluto, Giampiero,Baiti, Benedetta,Moro, Stefano,Boutorine, Alexandre,Prato, Maurizio
p. 405 - 413
(2007/10/03)
Synthesis of a hybrid fullerene-trimethoxyindole-oligonucleotide conjugate
The synthesis of novel functionalized fullerene derivatives is reported: a DNA minor groove binder such as trimethoxyindole-2-carboxylate (TMI) and an oligonucleotide chain have been covalently linked to C60 with the aim of duplicating DNA interactions for increasing sequence selectivity.
Bergamin,Da Ros,Spalluto,Boutorine,Prato
p. 17 - 18
(2007/10/03)
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