- Novel Myocyte Enhancer Factor 2 (MEF2) modulators
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The present disclosure provides novel compounds capable of functioning as Myoctye Enhancer Factor 2 (MEF2) modulators, as well as compositions, pharmaceutical formulations, methods of synthesis and kits. Also provided are methods of treating a condition regulatable by MEF2 and/or MEF2 cofactors using the compounds, compositions, pharmaceutical formulations, and kits provided herein.
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Paragraph 0105; 0108-0109
(2019/08/20)
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- 2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS
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The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.
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Page/Page column 86; 87
(2017/02/09)
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- NOVEL TRANSCRIPTION FACTOR MODULATORS
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The present disclosure provides novel compounds capable of functioning as transcription factor modulators, as well as compositions, pharmaceutical formulations, and kits. Also provided are methods of treating a condition regulatable by a transcription factor and/or cofactor using the compounds, compositions, pharmaceutical formulations, and kits provided herein.
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Paragraph 0178; 0183; 0184
(2014/09/29)
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- Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases
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HDAC inhibitors show great promise for the treatment of cancer. As part of a broader effort to explore the SAR of HDAC inhibitors, synthesis, biological evaluation, and molecular docking of novel Ugi products containing a zinc-chelating moiety are presented. One compound shows improved inhibitory potencies compared to SAHA, demonstrating that hindered lipophilic residues grafted on the peptide scaffold of the α-aminoacylamides can be favorable in the interaction with the enzyme.
- Grolla, Ambra A.,Podestà, Valeria,Chini, Maria Giovanna,Di Micco, Simone,Vallario, Antonella,Genazzani, Armando A.,Canonico, Pier Luigi,Bifulco, Giuseppe,Tron, Gian Cesare,Sorba, Giovanni,Pirali, Tracey
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experimental part
p. 2776 - 2785
(2010/02/28)
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- The synthesis of the vitamers of biotin
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An efficient synthetic pathway for the preparation of the vitamers of biotin which provides easy access to optically pure KAPA as well as diastereomeric mixtures of DAPA, DTB, and analogs thereof has been developed.
- Nudelman, Abraham,Nudelman, Ayelet,Marcovici-Mizrahi, Dana,Flint, Dennis
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p. 157 - 168
(2007/10/03)
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