- A comparison of some pyrolysis reactions of benzotriazoles, benzisoxazolones and benzisothiazolones
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The products of flash vacuum pyrolysis of N-acetyl, N-methyl, N-benzyl and N-heteroaryl-substituted benzotriazole, 2,1-benzoxazol-3-one and 2,1-benzothiazol-3-one have been compared. The pyrolysis of benzotriazoles and benzisoxazolones appears to involve an iminocarbene intermediate, although the N-benzyl analogues react by radical pathways. Benzisothiazolones appear to form iminoketene intermediates.
- Janowski, Wit K.,Prager, Rolf H.,Smith, Jason A.
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p. 3212 - 3216
(2007/10/03)
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- Non-photochemical rearrangements of o-nitrobenzyl compounds
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Three rearrangements of 2-nitrobenzyl compounds with increasingly complex structural changes are described. The first is a remarkably facile conversion of 2-nitrobenzyl triflate to 2-nitrosobenzaldehyde. The second is an unexpected formation of 1-acetyl-2
- Corrie, John E. T.,Gradwell, Michael J.,Papageorgiou, George
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p. 2977 - 2982
(2007/10/03)
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- Benzisoxazolones: Antimicrobial and antileukemic activity
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An unusual acid-mediated rearrangement of o-nitrostyrene oxide afforded 1-(hydroxymethyl)-2,1-benzisoxazol-3(1H)-one which exhibited broad-spectrum antimicrobial and cytotoxic activity. A number of analogues were prepared by employing a modified zinc-redu
- Wierenga,Evans,Zurenko
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p. 1212 - 1215
(2007/10/02)
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