Synthesis and spectroscopic properties of some new N,N'-disubstituted thioureas of potential biological interest
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Sarkis,Faisal
p. 137 - 140
(2007/10/02)
Anticonvulsant activity and succinate dehydrogenase inhibitory property of new substituted thiobarbiturates
Eight 1-aryl-3-(2-pyridyl)thiobarbiturates were synthesized and evaluated for their anticonvulsant property and their ability to inhibit succinate dehydrogenase activity of rat brain homogenates. These substituted thiobarbiturates (100 mg./kg., i.p.) provided 20-60% protection against pentylenetetrazol-induced convulsions in albino mice. Low toxicity of these compounds was reflected by their high approximate LD50 values which were found to range from 500-1000 mg/kg. All substituted thiobarbiturates (1mM) inhibited in vitro succinate dehydrogenase activity and the degree of inhibition ranged from 10-72%.