Conversion of trans- to cis-N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-thioxanthene-2-sulfonamide and recovery of the cis-isomer
Trans-N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-thioxanthene-2-sulfonamide is isomerized to the cis-isomer by contacting the trans-isomer with strong base in a polar organic solvent. By using an organic solvent in which the solubility of the cis-isomer is substantially less than that of the trans-isomer, the cis-isomer can be selectively precipitated from said solvent, thereby favoring additional isomerization to the cis-isomer in the supernatant, and separated.
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(2008/06/13)
Thioxanthene psychopharmacological agents. II. 9-(3-aminopropylidene)-N,N-dimethylthioxanthene-2-sulfonamides.
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Muren,Bloom
p. 17 - 23
(2007/10/04)
Chemical Properties
Appearance/Colour :yellow to yellow with a tan cast powder
