- IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
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Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula ( I ) represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.
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Page/Page column 66
(2008/06/13)
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- BROMINATION OF DIMETHYLACETALS WITH Br2-CHLOROTRIMETHYLSILANE-NaBr
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α-Bromodimethylacetals are obtained in excellent yields by treating dimethylacetals with Br2-NaBr-chlorotrimethylsilane in CH3OH/CH3CN (2:1). The method is suitable for large scale preparation.
- Bellesia, Franco,Boni, Monica,Ghelfi, Franco,Pagnoni, Ugo Maria
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p. 629 - 632
(2007/10/02)
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- THE MUKAIYAMA REACTION OF KETENE BIS(TRIMETHYLSILYL)ACETALS WITH α-HALO ACETALS - A CONVENIENT BUTENOLIDE SYNTHESIS
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Ketene bis(trimethylsilyl) acetals were reacted with α-halo acetals giving β-alkoxy-γ-halo acids which were converted to butenolides by reaction with equivalents of base.This constitutes a novel and short butenolide synthesis.
- Demnitz, F. W. J.
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p. 6109 - 6112
(2007/10/02)
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- Ketene Chemistry 2. A General Procedure for the Synthesis of 2-Alkoxycyclopropanecarboxylic Esters and Acids Starting from Aldehydes and Ketene
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Alkyl 3-alkoxy-4-bromocarboxylates are prepared by the Lewis acid-catalyzed reaction of α-bromoaldehyde acetals with ketene.Base-catalyzed cyclization of these intermediates affords 2-alkoxycyclopropanecarboxylic esters.
- Rasmussen, Preben Boedstrup,Boewadt, Soeren
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p. 114 - 117
(2007/10/02)
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- Method for the preparation of fragrances, and method for the preparation of perfume compositions
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The invention relates to a method for the preparation of both known and novel fragrances and flavors, and in particular to the preparation and use of the novel fragrance compound, 2,6-nonadiene nitrile, and to a novel method for the preparation of 4-heptynal as the starting product for the preparation of the 2,6-nonadiene nitrile fragrance compound.
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