- Micromolecular gelator, gel material, preparation method and application
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The invention provides a micromolecular gelator, a gel material, a preparation method and an application. The gelator is prepared by taking cheap and easily available phenyllactic acid as a raw material and introducing a hydrazide group and a hydrophobic alkyl chain through a simple and mature chemical reaction. The gelator can effectively gelate various organic solvents; the gel material formed by the gelator and methyl benzoate can quickly and efficiently remove phenol from sewage; the gelator can selectively gelate petroleum products such as gasoline, diesel oil, kerosene and lubricating oil, and crude oil in an oil-water mixture without the help of an additive; oil and water separation is achieved by simple operation; the gelator can be used for leakage management of the crude oil andthe petroleum products and is multifunctional; and in addition, the gelator has good recyclability and very good application prospects in the fields of phenol removal from the sewage, marine oil spilltreatment and the like.
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Paragraph 0044; 0049; 0050
(2018/11/22)
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- An efficient enzymatic aminolysis for kinetic resolution of aromatic α-hydroxyl acid in non-aqueous media
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A new and highly efficient enzymatic aminolysis approach for kinetic resolution of aromatic α-hydroxy acid in non-aqueous media has been developed. The corresponding α-hydroxyl acid ester was employed as the substrate, and commercially available Candida antarctica lipase B is used as the biocatalyst, anhydrous ammonia is the resolving agent. Reactions can be proceeded smoothly in organic solvent at ambient temperatures. High concentration of substrate is allowed due to the application of organic media and the products are obtained in yields of up to 49% with ee values of up to 99%, and with E value of >300, representing an appealing and promising protocol for large-scale preparations.
- Chen, Shan,Liu, Fuyan,Zhang, Kuan,Huang, Hansheng,Wang, Huani,Zhou, Jiaying,Zhang, Jing,Gong, Yiwei,Zhang, Dela,Chen, Yiping,Lin, Chang,Wang, Bo
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supporting information
p. 5312 - 5314
(2016/11/16)
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- Synthesis of new chiral ionic liquids from α-hydroxycarboxylic acids
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New functionalized optically active N-methylimidazolium ionic liquids with an asymmetric center at the β-position to the imdazole ring were synthesized as bromide salts from optically active α-hydroxycarboxylic acids. The bromide anions were exchanged by carboxylate anions with Amberlite IRA 400 ionic exchange resin.
- Poterala, Marcin,Plenkiewicz, Jan
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experimental part
p. 294 - 299
(2011/05/17)
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- Total synthesis of the antifungal depsipeptide petriellin A
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We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected lin
- Sleebs, Marianne M.,Scanlon, Denis,Karas, John,Maharani, Rani,Hughes, Andrew B.
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scheme or table
p. 6686 - 6693
(2011/10/18)
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- Zinc-catalyzed enantiospecific sp3-sp3 cross-coupling of α-hydroxy ester triflates with grignard reagents
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(Chemical Equation Presented) Zinc chloride does the trick and efficiently catalyzes the enantiospecific cross-coupling of α-hydroxy ester triflates with Grignard reagents under mild conditions. Enantiopure α-hydroxy esters are directly available from the chiral pool or by diazotization of α-amino acids. Substantial variations in both reacting partners are tolerated making this methodology an attractive alternative to enolate alkylation featuring a reversal of polarity.
- Studte, Christopher,Breit, Bernhard
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supporting information; experimental part
p. 5451 - 5455
(2009/03/12)
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- Trichosporon cutaneum-promoted deracemization of (±)-2-hydroxindan-1-one: a mechanistic study
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A mechanistic study of the deracemization of (±)-2-hydroxy-1-indanone mediated by the yeast Trichosporon cutaneum to afford pure (1S,2R)-1,2-indandiol is reported. The key aspect of the study was the use of pure (R)- and (S)-2-hydroxy-1-indanone enantiomers to ensure reliable conclusions. Experiments in the absence of yeast cells or using dead cells disclosed that the pure enantiomers were not racemized, which suggest that the whole dynamic kinetic resolution process is enzymatic in character. When living yeast cells were used the (R)-substrate was smoothly converted to (1S,2R)-1,2-indandiol, whilst the (S)-2-hydroxy-1-indanone was converted to the same diol through a more complex fashion, which requires a more lengthy oxidation-reduction pathway having the 1,2-indanedione as an achiral intermediate. An unexpected observation was that 1,2-indanone acts as a moderate inhibitor of the reductive enzymes acting in the conversion of (R)-2-hydroxy-1-indanone to (1S,2R)-1,2-indandiol.
- Cazetta, Tarcila,Lunardi, Ines,Conceicao, Gelson J.A.,Moran, Paulo J.S.,Rodrigues, J. Augusto R.
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p. 2030 - 2036
(2008/02/11)
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- Enantio-complementary deracemization of (±)-2-hydroxy-4- phenylbutanoic acid and (±)-3-phenyllactic acid using lipase-catalyzed kinetic resolution combined with biocatalytic racemization
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Deracemization of (±)-3-phenyllactic acid (1) and (±)-2-hydroxy-4-phenylbutanoic acid (2) was accomplished by lipase-catalysed kinetic resolution coupled to biocatalytic racemization of the non-reacting substrate enantiomers using Lactobacillus paracasei DSM 20008. Cyclic repetition of this sequence led to a single enantiomeric product from the racemate. Access to both enantiomers was achieved by switching between lipase-catalysed acyl-transfer and ester hydrolysis reactions. Both products constitute important building blocks for virus protease- and ACE-inhibitors, respectively.
- Larissegger-Schnell, Barbara,Glueck, Silvia M.,Kroutil, Wolfgang,Faber, Kurt
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p. 2912 - 2916
(2007/10/03)
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- Azacyclosteroid histamine-3 receptor ligands
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Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.
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Page/Page column 45
(2010/02/14)
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- AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS
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Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.
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Page/Page column 25; 94; 95
(2010/02/14)
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- Synthesis of isotopically labeled puromycin derivatives for kinetic isotope effect analysis of ribosome catalyzed peptide bond formation
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The mechanism by which the ribosome catalyze peptide bond formation remains controversial. Here we describe the synthesis of dinucleotides that can be used in kinetic isotope effect experiments to assess the transition state of ribosome catalyzed peptide
- Okuda, Kensuke,Seila, Amy C.,Strobel, Scott A.
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p. 12101 - 12112
(2007/10/03)
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- Synthesis and characterization of chiral N-O turns induced by α-aminoxy acids
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Chiral α-aminoxy acids of various side chains were synthesized with high optical purity starting from chiral α-amino acids. The conformations of diamides 13a-e, 15, and 16 were probed by using NMR, FT-IR, and CD spectroscopic methods as well as X-ray crystallography. The right-handed turns with eight-membered-ring intramolecular hydrogen bonds between adjacent residues (called the N-O turns) were found to be preferred for D-aminoxy acid residues, and they were independent of the side chains. The rigid chiral N-O turns should have great potential in molecular design.
- Yang,Li,Ng,Yan,Qu,Wu
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p. 7303 - 7312
(2007/10/03)
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- A simple procedure for the synthesis of enantiopure α-acetoxy ketones
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Cross-coupling reactions of α-acetoxy carboxylic acid chlorides with organocopper reagents, derived from Grignard reagents, cuprous bromide and lithium bromide, provide a simple and straightforward method for the synthesis of enantiopure α-acetoxy ketones.
- Babudri, Francesco,Fiandanese, Vito,Marchese, Giuseppe,Punzi, Angela
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p. 2431 - 2440
(2007/10/03)
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- A highly diastereoselective chiral pool based synthesis of cis- and trans- indan-1,2-diols
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Starting from the α-hydroxy acid chiral-pool, the 1R,2S- and 1S,2S- indan-1,2-diols have been prepared in a few steps with excellent diastereoselectivity.
- Sengupta, Saumitra,Mondal, Somnath
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p. 3469 - 3470
(2007/10/03)
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- Synthesis of optically active α-hydroxy acids by kinetic resolution through lipase-catalyzed enantioselective acetylation
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The lipase-catalyzed acetylation of a broad spectrum of racemic 2-hydroxy acids 1 to their 2-acetoxy acids 2 was shown to proceed with high enantioselectivity. Thus, the microbial lipases, in particular from Candida antarctica and Burkholderia species, are convenient biocatalysts for the synthesis of optically active 2-hydroxy acids in excellent enantioselectivity (ee values up to 99%). The absolute configurations of the 2-hydroxy acids 1 were assigned by comparison of the gas-chromatographic data with that of literature-known reference compounds, or by means of the exciton-coupled circular dichroism method (ECCD) on their bichromophoric 2-naphthoate 9-anthrylmethyl derivatives 3. These results establish that (S)-2-hydroxy acids 1 were preferentially acetylated by microbial lipases.
- Adam, Waldemar,Lazarus, Michael,Schmerder, Alexandra,Humpf, Hans-Ulrich,Saha-M?ller, Chantu R.,Schreier, Peter
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p. 2013 - 2018
(2007/10/03)
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- Chemistry of the mycalamides: Antiviral and antitumour compounds from a New Zealand marine sponge. Part 6. The synthesis and testing of analogues of the C(7)-C(10) fragment
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The key structural features associated with the potent cytotoxicity observed in the mycalamide, onnamide, pederin and theopederin series have been defined on the basis of structure-activity studies. A model pharmacophore structure has been proposed and selected examples, with modest bioactivity, synthesized.
- Abell, Andrew D.,Blunt, John W.,Foulds, Glenn J.,Munro, Murray H. G.
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p. 1647 - 1654
(2007/10/03)
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- Enantioselective Preparation of α-Acyloxy Ketones from α-Hydroxy and α-Amino Acids
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Various chiral α-acyloxy ketones have been easily prepared, in high yields with an excellent enantiomeric purity, by acylation of organomanganese reagents with the corresponding α-acyloxy carboxylic acid chlorides prepared from α-hydroxy and α-amino acids.
- Cahiez, Gerard,Metais, Eric
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p. 6449 - 6452
(2007/10/02)
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- The Synthesis of Peptide β-Lactams as Potential Protease Inhibitors
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β-Lactam analogues of a peptide which is a substrate/inhibitor of Angiotensin Converting Enzyme (ACE) have been designed as potential inhibitors of the enzyme.The synthesis of a series of these compounds is described and their absolute stereochemistry has been assigned by a combination of X-ray crystallography, chemical shift correlations, and nuclear Overhauser effect (n.O.e.) studies.
- Wharton, Clifford J.,Wrigglesworth, Roger,Rowe, Michael
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