- Design and construction of endo -functionalized multiferrocenyl hexagons via coordination-driven self-assembly and their electrochemistry
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The construction of a new family of endo-functionalized multiferrocenyl hexagons with various sizes via coordination-driven self-assembly is described. The structures of these novel metallacycles, containing several ferrocenyl moieties at their interior s
- Chen, Li-Jun,Li, Quan-Jie,He, Jiuming,Tan, Hongwei,Abliz, Zeper,Yang, Hai-Bo
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Read Online
- Bifunctional pillararene derivative ligand, metal organic cage and preparation method
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The invention discloses a bifunctional pillararene derivative ligand, a metal organic cage and a preparation method. The pillararene derivative ligand has a structure shown as a formula (I); a pillararene and tetraphenyl ethylene with large steric hindran
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Paragraph 0033; 0038; 0040
(2020/07/28)
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- Efficient and sustainable laccase-catalyzed iodination of: P -substituted phenols using KI as iodine source and aerial O2 as oxidant
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The laccase-catalyzed iodination of p-hydroxyarylcarbonyl- and p-hydroxyarylcarboxylic acid derivatives using KI as iodine source and aerial oxygen as the oxidant delivers the corresponding iodophenols in a highly efficient and sustainable manner with yields up to 93% on a preparative scale under mild reaction conditions.
- Sdahl, Mark,Conrad, Jürgen,Braunberger, Christina,Beifuss, Uwe
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p. 19549 - 19559
(2019/07/05)
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- Preparation method of amiodarone hydrochloride (by machine translation)
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The invention provides a preparation method, and relates to the technical field of drug synthesis, in particular to a preparation method of amiodarone hydrochloride. The invention uses methyl hydroxybenzoate as a main raw material, and sequentially undergoes a substitution reaction, etherification reaction, hydrolysis reaction, chloro reaction, a reaction, amination reaction and acidification, and the amiodarone hydrochloride. The preparation method provided by the invention does not need the process, reduces the use, reduces the environmental pollution, greatly reduces the environmental pollution and shortens the synthesis route while chlorination of 3, 5 - diiod -4 - (2 -hydroxyethoxy) - benzoic acid by using the thionyl chloride is reduced, and the synthetic route. The preparation method provided by the invention is simple in process, low in cost, small in pollution and high in yield. (by machine translation)
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Paragraph 0077-0079
(2019/08/12)
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- Method for synthesizing amiodarone impurity G and application of amiodarone impurity G
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The invention provides a method for synthesizing an amiodarone impurity G and application of the amiodarone impurity G, and relates to the technical field of chemical synthesis. According to the method for synthesizing the amiodarone impurity G, the amiod
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Paragraph 0054-0058
(2017/07/07)
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- Xanthine oxidase inhibitor and application thereof
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The invention discloses a xanthine oxidase inhibitor and application thereof. The xanthine oxidase inhibitor is a compound shown as a general formula (I) and is a pharmaceutically acceptable salt. The xanthine oxidase inhibitor, which is the compound and
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Paragraph 0097; 0098
(2017/08/26)
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- IMPROVED PROCESSES FOR THE PREPARATION OF SOFOSBUVIR AND INTERMEDIATES THEREOF
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The present disclosure provides new procedures and intermediates for the preparation of Sofosbuvir.
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Paragraph 00133
(2016/12/22)
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- Generation of 3-borylbenzynes, their regioselective Diels-Alder reactions, and theoretical analysis
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3-Borylbenzynes were generated in situ from 6-boryl-2-iodophenyl trifluoromethanesulfonates using i-PrMgCl·LiCl and applied to Diels-Alder reactions with substituted furans and pyrroles. The reactions allowed good functional group compatibility and produced the cycloadducts in high yields with high distal selectivities. Effective conversion of the boryl group of the products was achieved. A series of these reactions provides a new method for producing multifunctionalized benzo-fused aromatic compounds. Additionally, the regioselectivities of these Diels-Alder reactions were theoretically analyzed by DFT calculations to find that the reactions were mainly controlled by the electrostatic effect and aryne distortion caused by the boryl group.
- Takagi, Akira,Ikawa, Takashi,Kurita, Yurio,Saito, Kozumo,Azechi, Kenji,Egi, Masahiro,Itoh, Yuji,Tokiwa, Hiroaki,Kita, Yasuyuki,Akai, Shuji
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supporting information
p. 4338 - 4352
(2013/06/04)
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- Regiocomplementary cycloaddition reactions of boryl- and silylbenzynes with 1,3-dipoles: Selective synthesis of benzo-fused azole derivatives
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Benzo-fused nitrogen-containing heterocycles are abundant in biologically active compounds. One of the most important methods for preparing such heterocycles is the (3 + 2) cycloaddition reaction of benzynes with 1,3-dipolar compounds. However, the reacti
- Ikawa, Takashi,Takagi, Akira,Goto, Masahiko,Aoyama, Yuya,Ishikawa, Yoshinobu,Itoh, Yuji,Fujii, Satoshi,Tokiwa, Hiroaki,Akai, Shuji
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p. 2965 - 2983
(2013/06/26)
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- Preparation and regioselective Diels-Alder reactions of borylbenzynes: Synthesis of functionalized arylboronates
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(Figure Presented) B+ [4+2]: 3-Borylbenzynes undergo Diels-Alder reactions with substituted furans and pyrroles to give highly functionalized arylboronic acid derivatives with either good or exclusive regioselectivities (see picture). The effect of the boryl group on the regioselectivity arises from electronic rather than steric effects.
- Ikawa, Takashi,Takagi, Akira,Kurita, Yurio,Saito, Kozumo,Azechi, Kenji,Egi, Masahiro,Kakiguchi, Keisuke,Kita, Yasuyuki,Akai, Shuji
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supporting information; experimental part
p. 5563 - 5566
(2010/09/05)
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- Construction of endo-functionalized two dimensional metallacycles via coordination-driven self-assembly
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(Figure Presented) The synthesis of three endofunctionalized two-dimensional supramolecular metallacycles including two [2+2] rhomboids (5 and 6) and a [3+3] hexagon (7) is reported. The resulting self-assembled supramolecular structures, containing sever
- Zhao, Liang,Ghosh, Koushik,Zheng, Yao-Rong,Stang, Peter J.
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experimental part
p. 8516 - 8521
(2009/12/28)
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- An effective method for the synthesis of 13C-labeled polyprenylhydroxybenzoic acids
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The synthesis of side-chain 13C-labeled geranylgeranyl-4- hydroxybenzoic acids and geranylgeranyl-3,4-dihydroxybenzoic acids is described. The synthesis starts from O-protected methyl hydroxyiodobenzoates, which are transformed into Grignard re
- Lang, Martin,Steglich, Wolfgang
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p. 1019 - 1027
(2007/10/03)
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- HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated-amyloid levels or-amyloid deposits, particularly Alzheimer's disease.
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- 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
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This invention provides compounds of Formula I having the structure wherein:B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
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- Fluorescent chemosensors based on energy migration in conjugated polymers: The molecular wire approach to increased sensitivity
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We demonstrate herein how conjugated polymers (molecular wires) can be used to interconnect (wire in series) receptors to produce fluorescent chemosensory systems with sensitivity enhancements over single receptor analogues. The enhancement mechanism in t
- Zhou, Qin,Swager, Timothy M.
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p. 12593 - 12602
(2007/10/03)
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- Iodination of Phenols by Use of Benzyltrimethylammonium Dichloroiodate(1-)
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The reaction of phenols with benzyltrimethylammonium dichloroiodate(1-) in dichloromethane-methanol in the presence of CaCO3 or NaHCO3 for several hours at room temperature gave iodophenols in good yields.
- Kajigaeshi, Shoji,Kakinami, Takaaki,Yamasaki, Hiromichi,Fujisaki, Shizuo,Kondo, Manabu,Okamoto, Tsuyoshi
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p. 2109 - 2112
(2007/10/02)
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