- Synthesis and properties of chiral internally branched PAMAM-dendrimers
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Improved synthetic methodology for the synthesis of internally branched chiral poly(amidoamine) (PAMAM) dendrons and dendrimers has been developed and the compounds have been characterized by NMR spectroscopy, IR spectroscopy, and optical rotation measurements. The dendrons and dendrimers show increased degree of internal hydrogen bonding upon increasing generation and the presence of different types of amide-protons in the compounds is indicative of the existence of a tertiary structure in these PAMAM-dendrimers.
- Petersen, Johannes F.,Tortzen, Christian G.,Pittelkow, Michael,Christensen, J?rn B.
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p. 1109 - 1116
(2015/02/19)
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- NOVEL HETEROCYCLYL COMPOUNDS
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The invention is concerned with novel heterocyclyl compounds of formula (I): wherein A, X, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR2 receptor, CCR5 receptor and/or CCR3 receptor and may be used as medicaments.
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Page/Page column 39
(2010/02/17)
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- AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE
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The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain amino-ethyl-amino-aryl (AEAA) compounds which, inter alia, inhibit protein kinase D (PKD) (e.g., PKD1, PKD2, PKD3). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PKD, and in the treatment of diseases and conditions that are mediated by PKD, that are ameliorated by the inhibition of PKD, etc., including proliferative conditions such as cancer, etc.
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Page/Page column 134
(2009/10/06)
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- Thiazolo (4,5-D) pyrimidine compounds
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The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therap
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Page/Page column 19
(2008/06/13)
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