- Synthesis of n-methyl benzenemethane sulfonamide substituted carbazoles and pyrazoles
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Cyclization of 1-(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride (2) with cyclohexanone (3)/N-methyl-4-piperidone (5) afforded the corresponding N-methyl-1-(2,3,4,9-tetrahydro-1H-carbazol-6-yl)methanesulfonamide (4) and N-methyl-1-(2-methyl- 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl) methane sulfonamide (6). Condensation of compound 2 with substituted aryl β-diketones gave the novel N-methyl-1-[4-(3-methyl-5-phenyl-1H-pyrazol-1- yl)phenyl]methanesulfonamide (8). All the synthesized compounds were characterized by their FT-IR, 1H NMR and mass spectral data.
- Rao, B. Venugopala,Hariharakrishnan,Dubey
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scheme or table
p. 1191 - 1194
(2012/08/07)
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- NOVEL PROCESS
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The present invention relates to a novel process for the preparation of almotriptan and pharmaceutically acceptable salts thereof, which affords product conveniently and efficiently with commercially acceptable yields and purity. The present invention also relates to a novel synthetic intermediate used in the process.
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Page/Page column 13; 15-18
(2009/03/07)
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- PREPARATION AND UTILITY OF SUBSTITUTED INDOLES
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Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.
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Page/Page column 39
(2008/06/13)
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- CONVERSION OF AROMATIC DIAZONIUM SALT TO ARYL HYDRAZINE
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The present invention relates to the preparation of aryl hydrazines and their salts by treating aryl diazonium salts with triphenyl phosphine followed by hydrolysis of the resulting triphenyl-aryl hydrazyl phosphonium salt to get aryl hydrazine or its sal
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Page/Page column 7
(2008/06/13)
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- Synthesis of 5-(sulfamoylmethyl)indoles
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The synthesis of 5-(sulfamoylmethyl)indoles bearing a two-carbon chain at C-3 (aminoethyl, acetate, hydroxyethyl, ethyl) either by the Grandberg modification of the Fischer indolization or by intramolecular Heck reaction of suitable o-halotrifluoroacetanilides is reported.
- Bosch, Joan,Roca, Tomàs,Armengol, Montserrat,Fernández-Forner, Dolors
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p. 1041 - 1048
(2007/10/03)
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