- Polyfluoroalkoxy phosphonic and phosphinic acid derivatives: II. Reversible esterase inhibitors
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Polyfluoroalkyl esters of phosphoric, alkylphosphonic and 1-hydroxypolyfluoroalkylphosphonic acids exhibited significant antiesterase activity against various esterases of animal and microbial origin. Moreover, with some compounds reversible inhibition of enzymes was observed due to the specific influence of hydrophobic fragments of the target products.
- Krutikova,Krutikov,Erkin
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experimental part
p. 434 - 439
(2010/08/04)
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- Polyfluoroalloxy phosphonic and phosphinic acid derivatives: I. 1-Hydroxy-2,2,2-trichloroethylphosphinates
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Polyfluoroalkyl esters of 1-hydroxy-2,2,2-trichloroethylphosphonic and aryl(alkyl-)phosphinic acids exhibited antienzyme activity towards esterases of animal and microbial origin. A good correlation is observed between high antiesterase activity of the target compounds and their physicochemical parameters, characterizing their structure.
- Krutikova,Krutikov,Erkin
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scheme or table
p. 428 - 433
(2010/08/04)
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- Process for hydroxyalkylation of fluorinated alcohols
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Mono O-hydroxyalkylated derivatives of 1,1-dihydroperfluorinated or 1H,1-alkylperfluorinated alcohols are prepared by reacting the alcohols with alkylene carbonates at a temperature of at least 60° C. in the presence of a one- or two-part catalyst. The catalyst is a nitrogenous base, optionally in combination with a tetraalkylammonium halide. The O-hydroxyalkylated derivatives are useful non-ionic surfactants and emulsifiable compounds for fire extinguishing systems.
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- COMPOUNDS WITH A TELLURIUM-NITROGEN BOND. Y. POLYFLUOROALKOXYHALOGENO- AND POLYFLUOROALKOXYAMINOTELLURANES
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The reaction of tetrakis(polyfluoroalkoxy)telluranes with tellurium tetrahalides leads to the production of mixed polyfluoroalkoxyhalogenotelluranes.The reaction of the polyfluoroalkoxyhalogenotelluranes with silylated secondary amines and hexamethyldisilylbenzenesulfonamide leads to the formation of derivatives of hydroxyaminotelluranes and N,N-bis(phenylsulfonyl)tellurium diimide.
- Stukalo, E. A.,Yur'eva, E. M.,Markovskii, L. N.
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p. 2305 - 2309
(2007/10/02)
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- COMPOUNDS WITH A TELLURIUM-NITROGEN BOND. IV. SYNTHESIS OF POLYFLUOROALKOXYTELLURANES AND DERIVATIVES OF N-ARYLSULFONYLIMIDOTELLUROUS ACID
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In the reaction of tellurium tetrafluoride with trimethylsilyl-α,α,ω-trihydroperfluoroalkanols stage-by-stage substitution of the fluorine atoms by polyfluoroalkyl groups occurs with the formation of stable mono-, bis-, and tris(α,α,ω-trihydroperfluoroalkoxy)-fluorotelluranes and tetrakis(α,α,ω-trihydroperfluoroalkoxy)telluranes.The reaction of the polyfluoroalkoxytelluranes with sulfonamides or their disilylated derivatives leads to the formation of derivatives of N-arylsulfonylimidotellurous acid.
- Markovskii, L. N.,Stukalo, E. A.,Ogloblin, A. N.,Iksanova, S. V.
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- (POLYFLUOROALKOXY)-N,N-DIALKYLAMINOFLUOROSULFURANES AND TRIS(POLYFLUOROALKOXY)-N,N-DIALKYLAMINOSULFURANES
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(Polyfluoroalkoxy)-N,N-dialkylaminodifluorosulfuranes, bis(polyfluoroalkoxy)-N,N-dialkylaminofluorosulfuranes, and tris(polyfluoroalkoxy)-N,N-dialkylaminosulfuranes were obtained by the reaction of N,N-dialkylaminotrifluorosulfuranes with trimethylsilyloxypolyfluoroalkanes.
- Markovskii, L. N.,Bobkova, L. S.,Pashinnik, V. E.
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p. 1699 - 1703
(2007/10/02)
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- α,α,ω-TRIHYDROPERFLUOROALKOXYFLUOROSULFURANES AND TETRAKIS-(α,α,ω-TRIHYDROPERFLUOROALKOXY)SULFURANES
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The reaction of α,α,ω-trihydroperfluoroalkanols with sulfur tetrafluoride in the presence of alkali-metal fluorides gives α,α,ω-trihydroperfluoroalkoxytrifluorosulfuranes.The latter disproportionate with the release of sulfur tetrafluoride and the formation of stable tetrakis(α,α,ω-trihydroperfluoroalkoxy)sulfuranes.
- Markovskii, L. N.,Bobkova, L. S.,Pashinnik, V. E.,Iksanova, S. V.
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p. 409 - 412
(2007/10/02)
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