- General Platform for the Conversion of Isoxazol-5-ones to 3,5-Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross-Coupling Strategies
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A general platform for the conversion of isoxazol-5-ones to 3,5-disubstituted isoxazoles has been developed via a two-step strategy. The first step leads to the formation of 5-(pseudo)halogenated isoxazoles, while in the second, a variety of heteroalkyl-, heteroaryl-, alkyl-, alkenyl-, alkynyl- and aryl-chains can be installed via nucleophilic substitutions or palladium catalyzed cross-coupling reactions.
- Fernandes, Alessandra A. G.,da Silva, Amanda F.,Okada, Celso Y.,Suzukawa, Vitor,Cormanich, Rodrigo A.,Jurberg, Igor D.
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p. 3022 - 3034
(2019/05/17)
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- Transformations of gem-dibromoarylcyclopropanes under nitrosation conditions on treatment with NOCl·(SO3)n
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The reaction of 2-aryl-1,1-dibromocyclopropanes with adduct NOCl·(SO3)n leading to 3-aryl-5-bromoisoxazoles as a result of nitrosation—heterocyclization of the cyclopropane ring was studied. The reaction is accompanied with electroph
- Bondarenko,Gavrilova, A. Yu.,Nikolaeva,Zyk
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p. 1225 - 1231
(2017/02/05)
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- Nitrosation of 2-aryl-1,1-dibromocyclopropanes: Synthesis of 3-aryl-5-bromoisoxazoles
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An efficient transformation of 2-aryl-1,1-dibromocyclopropanes under the action of sulfur trioxide activated nitrosyl chloride has been developed, providing a series of arylated 5-bromoisoxazoles with good yields. It is noteworthy that under the reported
- Bondarenko, Oksana B.,Vinogradov, Aleksandr A.,Danilov, Pavel A.,Nikolaeva, Svetlana N.,Gavrilova, Anna Yu.,Zyk, Nikolai V.
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p. 6577 - 6579
(2015/11/09)
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