- Application of Mefoxin (cefoxitin sodium) pharmaceutical preparation in infection prevention in gastrointestinal surgery
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The present invention provides cefoxitin sodium or a composition thereof, a preparation process of the cefoxitin sodium or the composition thereof, a prescribed preparation, a compound preparation, and use. In the cefoxitin sodium or the composition thereof, the mass content of the cefoxitin (C16H17N3O7S2) is 92% or above on an anhydrous basis. The cefoxitin sodium or the composition thereof has good quality stability and a uniform particle size range, can reduce the process difficulty for preparing preparations, can improve clinical curative effects and safety, and can be used for gastrointestinal surgery infection prevention and postoperative infection treatment.
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Paragraph 0133; 0137; 0138; 0142; 0143; 0147
(2019/11/13)
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- Application of cefoxitin sodium pharmaceutical preparations in preoperative infection prevention for transvaginal hysterectomy, laparoscopic hysterectomy and cesarean section
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The present invention provides cefoxitin sodium or a composition thereof, a preparation method of the cefoxitin sodium or the composition thereof, a prescribed preparation, a compound preparation, anduse. In the cefoxitin sodium or the composition thereof, the mass content of the cefoxitin is 93% or above. The cefoxitin sodium or the composition thereof has good quality stability and a low impurity content, facilitating improvement in clinical curative effects and safety. The cefoxitin sodium or the composition thereof has a uniform particle size range, facilitating reduction in the process difficulty for preparing preparations. The cefoxitin sodium or the composition thereof can be used for preoperative infection prevention and postoperative infection treatment for transvaginal hysterectomy, laparoscopic hysterectomy and cesarean section.
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- Head west spore Ding Na method for the preparation of
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The invention discloses a preparation method of cefoxitin sodium. The preparation method comprises the following steps: (1) bromizing, for example, the site 7 of a main nucleus of cefalotin by using an NBS (N-bromosuccinimide) reagent to form a bromination compound; performing nucleophilic substitution at the site 5 by using a methoxyl group to generate an intermediate IV; (2) performing acyl group hydrolysis on the site 3 of the intermediate IV to obtain an intermediate V; (3) substituting hydrogen atoms on the hydroxyl group by using chloriosulfonyl isocyanate, and then hydrolyzing to obtain the cefoxitin sodium. The method has the advantages of simple process, high product yield, high purity and high reaction selectivity; no special equipment is used in the production; the preparation method is suitable for industrial production.
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Paragraph 0042-0044
(2017/03/14)
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