Method for preparing diclosan through Baeyer-Villiger oxidation
The invention provides a method for preparing diclosan by using urea peroxide as an oxidizing agent. Particularly, the method comprises the following steps: (1) oxidizing 5-chloro-2-(4-chloro-phenoxy)-acetophenone in an inert solvent by using urea peroxide as an oxidizing agent to obtain an intermediate I; and (2) hydrolyzing the intermediate I to obtain the diclosan. The method is safe in production process, mild in reaction and suitable for industrial production.
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Paragraph 0010; 0032; 0010; 0037-0051
(2021/07/01)
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