- Synthesis and Characterization of Near-Infrared Emissive Chiral π-Conjugated Polymers Incorporating Perylenyl Moieties with Visible-Light Absorption
-
A novel set of multifunctional optically active π-conjugated polymers incorporating perylenyl moieties, were designed and synthesized. Chirality transfer and amplification from chiral unit to the main-chain backbone in dilute solution was achieved, which was closely related to the stereocenter in the pendant of a π-conjugated polymer. In addition, annealed films of these polymers exhibited near-infrared emission by direct absorption of visible light, resulting from the introduction of a strong fluorophore perylenyl moiety. Such a design strategy opens up new perspectives for the future development of novel optically active materials with near-infrared emission for photonic applications.
- Li, Junfeng,Chen, Ying,Yang, Chenglong,Lai, Wen-Yong
-
-
Read Online
- Thermodynamic Characterization of Surface and Solubility of 5-((S)-3,7-Dimethyloctyloxy)-2-[[[4-(octyloxy)phenyl]imino]methyl]phenol Liquid Crystal with Some Solvents
-
The inverse gas chromatography method was used to obtain dispersive surface energy, surface acidity or basicity constants, mole fraction activity coefficients of the solvents at infinite dilution for a new salicylaldimine based chiral calamitic liquid crystal 5-((S)-3,7-dimethyloctyloxy)-2-[[[4-(octyloxy)phenyl]imino]methyl]phenol (DOPIMP). The dispersive surface energy of DOPIMP was estimated as 41.1 mJ/m2 at 30 °C and decreased with temperature. The specific free energy, enthalpy, and entropy of adsorption of the selected polar solvents on the liquid crystal were determined. The values of adsorption enthalpy were correlated with both donor and acceptor numbers of the solvents to quantify acidic KA and basic KD parameters of the liquid crystal surface. The results indicated that the surface of DOPIMP is basic. The retention diagrams of n-hexane, n-heptane, n-octane, n-nonane, n-decane, undecane, ethyl acetate, n-butyl acetate, iso-butyl acetate, toluene, ethylbenzene, n-propylbenzene, and chlorobenzene on the DOPIMP were plotted as straight lines using the net retention volumes at temperatures between 368.2 and 398.2 K. The values of activity coefficients indicated that DOPIMP was better soluble in long chain alkanes. Negatively signed partial molar Gibbs energies of mixing were obtained at infinite dilution of studied solvents.
- Mutlu Yanic, Serap,Cakar, Fatih,Ocak, Hale,Karaman, Ferdane,Cankurtaran, Ozlem,Bilgin Eran, Belklz
-
-
Read Online
- Light-driven supramolecular chirality in propeller-like hydrogen-bonded complexes that show columnar mesomorphism
-
(Graph Presented) Shine a light! Columnar mesomorphic assembles of propeller-like hydrogen-bonded complexes show a chiral photo-response upon irradiation with circularly polarized light (CPL) of a given handedness (see picture). The materials can behave as a supramolecular switch that undergoes helix inversion when irradiated with the oppositely polarized light.
- Vera, Francisco,Tejedor, Rosa M.,Romero, Pilar,Barbera, Joaquin,Ros, M. Blanca,Serrano, Jose Luis,Sierra, Teresa
-
-
Read Online
- A supramolecular helix that disregards chirality
-
The functions of complex crystalline systems derived from supramolecular biological and non-biological assemblies typically emerge from homochiral programmed primary structures via first principles involving secondary, tertiary and quaternary structures. In contrast, heterochiral and racemic compounds yield disordered crystals, amorphous solids or liquids. Here, we report the self-assembly of perylene bisimide derivatives in a supramolecular helix that in turn self-organizes in columnar hexagonal crystalline domains regardless of the enantiomeric purity of the perylene bisimide. We show that both homochiral and racemic perylene bisimide compounds, including a mixture of 21 diastereomers that cannot be deracemized at the molecular level, self-organize to form single-handed helical assemblies with identical single-crystal-like order. We propose that this high crystalline order is generated via a cogwheel mechanism that disregards the chirality of the self-assembling building blocks. We anticipate that this mechanism will facilitate access to previously inaccessible complex crystalline systems from racemic and homochiral building blocks.
- Roche, Cécile,Sun, Hao-Jan,Leowanawat, Pawaret,Araoka, Fumito,Partridge, Benjamin E.,Peterca, Mihai,Wilson, Daniela A.,Prendergast, Margaret E.,Heiney, Paul A.,Graf, Robert,Spiess, Hans W.,Zeng, Xiangbing,Ungar, Goran,Percec, Virgil
-
-
Read Online
- Synthesis, preparation, and characterization of liquid crystal/organo-montmorillonite nanocomposites
-
A new chiral calamitic liquid crystal 4′-((S)-3,7-dimethyloctyloxy)phenyl 4-(10-undecen-1-yloxy)benzoate (DOPUB) has been synthesized and characterized by spectroscopic methods (1H-NMR and 13C-NMR). The focus is on the preparation of the nanocomposites of new chiral calamitic liquid crystal DOPUB/Organo-montmorillonite clay (OMMT) by solution intercalation method addition with OMMT contents 2.5, 5, and 7.5 wt% and determination of the morphology, thermal behavior, and crystalline properties of liquid crystal DOPUB/OMMT. Montmorillonite (MMT) modified by cationic surfactant cetyltrimethylammonium bromide (CTAB) for increasing the interaction of clay with DOPUB liquid crystal. The characterization of clay minerals and nanocomposites was investigated by X-ray diffraction. The mesomorphic behavior of liquid crystal (DOPUB) and the nanocomposites was investigated by differential scanning calorimetry (DSC) and optical polarizing microscopy (PM).
- Yanic, Serap Mutlu,Guzeller, Dilek,Ocak, Hale,Cakar, Fatih,Erol, Ismail,Cankurtaran, Ozlem,Eran, Belkis Bilgin
-
-
Read Online
- A study of the thermodynamical interactions with solvents and surface characterisation of liquid crystalline 5-((S)-3,7-dimethyloctyloxy)-2-[[[4-(dodecyloxy)phenyl]imino]-methyl]phenol by inverse gas chromatography
-
An inverse gas chromatography (IGC) study of thermodynamic interactions of a new chiral calamitic liquid crystalline 5-((S)-3,7-Dimethyloctyloxy)-2-[[[4-(dodecyloxy)phenyl]imino]methyl]phenol (DODPIMP) with some solvents was presented. The retention diagrams of the solvents on the DODPIMP were plotted by specific retention volumes, Vg0 at temperatures between 373.2 and 393.2?K. The Flory-Huggins interaction parameter, χ12∞, the weight fraction activity coefficient, Ω1∞ and selectivity coefficients, α, of the structural isomers were determined for the DODPIMP liquid crystal. To characterize the surface properties of, retention diagrams of several non-polar and polar solvents on the DODPIMP were plotted by net retention volumes, VN in the temperature range from 303.2 to 318.2?K. The dispersive surface energy, the thermodynamic adsorption parameters and the acid–base constants of the compound in the crystalline phase were determined. The results indicated a basic character for the surface of DODPIMP at the studied conditions.
- Ocak, Hale,Mutlu-Yanic, Serap,Cakar, Fatih,Bilgin-Eran, Belkis,Guzeller, Dilek,Karaman, Ferdane,Cankurtaran, Ozlem
-
-
Read Online
- Large Faraday Rotation in Optical-Quality Phthalocyanine and Porphyrin Thin Films
-
The magneto-optical phenomenon known as Faraday rotation involves the rotation of plane-polarized light as it passes through an optical medium in the presence of an external magnetic field oriented parallel to the direction of light propagation. Faraday rotators find applications in optical isolators and magnetic-field imaging technologies. In recent years, organic thin films comprised of polymeric and small-molecule chromophores have demonstrated Verdet constants, which measure the magnitude of rotation at a given magnetic field strength and material thickness, that exceed those found in conventional inorganic crystals. We report herein the thin-film magnetic circular birefringence (MCB) spectra and maximum Verdet constants of several commercially available and newly synthesized phthalocyanine and porphyrin derivatives. Five of these species achieved maximum Verdet constant magnitudes greater than 105 deg T-1 m-1 at wavelengths between 530 and 800 nm. Notably, a newly reported zinc(II) phthalocyanine derivative (ZnPc-OT) reached a Verdet constant of -33 × 104 deg T-1 m-1 at 800 nm, which is among the largest reported for an organic material, especially for an optical-quality thin film. The MCB spectra are consistent with resonance-enhanced Faraday rotation in the region of the Q-band electronic transition common to porphyrin and phthalocyanine derivatives, and the Faraday A-term describes the electronic origin of the magneto-optical activity. Overall, we demonstrate that phthalocyanines and porphyrins are a class of rationally designed magneto-optical materials suitable for applications demanding large Verdet constants and high optical quality.
- Nelson, Zachary,Delage-Laurin, Leo,Peeks, Martin D.,Swager, Timothy M.
-
supporting information
p. 7096 - 7103
(2021/05/29)
-
- The synthesis and dielectric properties of a new phenylbenzoate-based calamitic liquid crystal
-
The dielectric investigation has a great importance in liquid crystal studies as a supportive method to DSC for a complete characterization of liquid crystals as well as in the electronic applications. In this study, the synthesis, mesomorphic characterization and dielectric properties of a new phenylbenzoate-based three-ring calamitic liquid crystal which composed of ester linking groups, (S)-3,7-dimethyloctyloxy chiral unit at one of terminals and n-octyloxy chain at the other end of the molecule, have been reported. The new calamitic liquid crystal 4-[4-((S)-3,7-dimethyloctyloxy)phenoxy)carbonyl]phenyl 4-(n-octyloxy)benzoate (DPCPB) has been characterized using 1H, 13C-NMR and MS-QTOF. The liquid crystalline behavior of the target compound has been investigated by differential scanning calorimetry and optical polarizing microscopy. DPCPB exhibits an enantiotropic non-tilted smectic mesophase in a wide temperature range. The real and imaginary dielectric constant, conductivity mechanism, impedance and dielectric relaxation mechanism of DPCPB have been investigated depending on frequency at different temperatures.
- Ahlatc?o?lu ?zerol, Esma,Ocak, Hale,Bilgin Eran, Belk?z,Karavelio?lu, Selvi
-
p. 225 - 232
(2020/08/10)
-
- Extraordinary magnetic field effects on the LC phases of homochiral and racemic 4-cyanoresorcinol-based diamagnetic bent-core mesogens
-
4-Cyanoresorcinol based bent-core compounds combining one branched chiral with one achiral linear end-chain have been synthesized in enatiomerically pure and one compound also in racemic form. All homochiral compounds form a chiral cybotactic nematic phase at relatively low temperature with a selective reflection ranging from the near IR to near UV. For the compound with the longest chains superparaelectric and antiferroelectric switching smectic phases were observed, whereas the corresponding racemate is non-polar. This is attributed to sterically induced polarization by the denser packing of uniform enantiomers due to chirality synchronization of the helical conformers. For the racemic mixture this chirality synchronization requires additional surface stabilization. There are unprecedented effects of an applied magnetic field (1 T) on the LC phases, leading to a layer shrinkage by 6-13% for the enantiomer and a layer expansion by 5-8% for the racemate. It is proposed that the magnetic field couples with the π-systems of the almost rod-like molecules. For the racemate this increases the core order, whereas for the enantiomer the reduction of the heliconical twist is considered to provide the major effect. These magnetic field effects could lead to new applications of chiral LC materials at the cross-over between rod-like and bent shapes.
- Ocak, Hale,Bilgin Eran, Belk?z,Nuray, Sevgi,?zkonstanyan, Aykun,Poppe, Silvio,Tschierske, Carsten
-
p. 1895 - 1910
(2021/03/01)
-
- Novel tdp1 inhibitors based on adamantane connected with monoterpene moieties via heterocyclic fragments
-
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison, such as topotecan, thus, decreasing their efficacy. Compounds containing adamantane and monoterpenoid residues connected via 1,2,4-triazole or 1,3,4-thiadiazole linkers were synthesized and tested against Tdp1. All the derivatives exhibited inhibition at low micromolar or nanomolar concentrations with the most potent inhibitors having IC50 values in the 0.35–0.57 μM range. The cytotoxicity was determined in the HeLa, HCT-116 and SW837 cancer cell lines; moderate CC50 (μM) values were seen from the mid-teens to no effect at 100 μM. Furthermore, citral derivative 20c, α-pinene-derived compounds 20f, 20g and 25c, and the citronellic acid derivative 25b were found to have a sensitizing effect in conjunction with topotecan in the HeLa cervical cancer and colon adenocarcinoma HCT-116 cell lines. The ligands are predicted to bind in the catalytic pocket of Tdp1 and have favorable physicochemical properties for further development as a potential adjunct therapy with Top1 poisons.
- Chepanova, Arina A.,Dyrkheeva, Nadezhda S.,Ilina, Ekaterina S.,Korchagina, Dina V.,Lavrik, Olga I.,Mozhaitsev, Evgenii S.,Munkuev, Aldar A.,Reynisson, Jóhannes,Salakhutdinov, Nariman F.,Suslov, Evgeniy V.,Volcho, Konstantin P.,Zakharenko, Alexandra L.,Zakharova, Olga D.
-
-
- New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections
-
Currently, the spectrum of agents against orthopoxviruses, in particular smallpox, is very narrow. Despite the fact that smallpox is well controlled, there is, for many reasons, a real threat of epidemics associated with this or a similar virus. In order to search for new low molecular weight orthopoxvirus inhibitors, a series of amides combining adamantane and monoterpene moieties were synthesized using 1- and 2-adamantanecarboxylic acids as well as myrtenic, citronellic and camphorsulfonic acids as acid components. The produced compounds exhibited high activity against the vaccinia virus (an enveloped virus belonging to the poxvirus family), which was combined with low cytotoxicity. Some compounds had a selectivity index higher than that of the reference drug cidofovir; the highest SI = 1123 was exhibited by 1-adamantanecarboxylic acid amide containing the (-)-10-amino-2-pinene moiety. The produced compounds demonstrated inhibitory activity against other orthopoxviruses: cowpox virus (SI = 30-406) and ectromelia virus (mousepox virus, SI = 39-707). This journal is
- Agafonov, Alexander P.,Bormotov, Nikolay I.,Korchagina, Dina V.,Maksyutov, Rinat A.,Mozhaytsev, Evgenii S.,Salakhutdinov, Nariman F.,Serova, Olga A.,Shishkina, Larisa N.,Suslov, Evgenii V.,Volcho, Konstantin P.,Yarovaya, Olga I.
-
p. 1185 - 1195
(2020/11/03)
-
- Environmentally responsible, safe, and chemoselective catalytic hydrogenation of olefins: ppm level Pd catalysis in recyclable water at room temperature
-
Textbook catalytic hydrogenations are typically presented as reactions done in organic solvents and oftentimes under varying pressures of hydrogen using specialized equipment. Catalysts new and old are all used under similar conditions that no longer reflect the times. By definition, such reactions are both environmentally irresponsible and dangerous, especially at industrial scales. We now report on a general method for chemoselective and safe hydrogenation of olefins in water using ppm loadings of palladium from commercially available, inexpensive, and recyclable Pd/C, together with hydrogen gas utilized at 1 atmosphere. A variety of alkenes is amenable to reduction, including terminal, highly substituted internal, and variously conjugated arrays. In most cases, only 500 ppm of heterogeneous Pd/C is sufficient, enabled by micellar catalysis used in recyclable water at room temperature. Comparison with several newly introduced catalysts featuring base metals illustrates the superiority of chemistry in water.
- Gallou, Fabrice,Gao, Eugene S.,Lipshutz, Bruce H.,Takale, Balaram S.,Thakore, Ruchita R.
-
supporting information
p. 6055 - 6061
(2020/10/14)
-
- Nanostructured Micelle Nanotubes Self-Assembled from Dinucleobase Monomers in Water
-
Despite the central importance of aqueous amphiphile assemblies in science and industry, the size and shape of these nano-objects is often difficult to control with accuracy owing to the non-directional nature of the hydrophobic interactions that sustain them. Here, using a bioinspired strategy that consists of programming an amphiphile with shielded directional Watson–Crick hydrogen-bonding functions, its self-assembly in water was guided toward a novel family of chiral micelle nanotubes with partially filled lipophilic pores of about 2 nm in diameter. Moreover, these tailored nanotubes are successfully demonstrated to extract and host molecules that are complementary in size and chemical affinity.
- Aparicio, Fátima,Casado, Santiago,Chamorro, Paula B.,Chamorro, Raquel,González-Rodríguez, David
-
supporting information
p. 17091 - 17096
(2020/07/30)
-
- Enantioselective Synthesis and Activity of All Diastereoisomers of (E)-Phytal, a Pheromone Component of the Moroccan Locust, Dociostaurus maroccanus
-
The Moroccan locust, Dociostaurus maroccanus (Thunberg, 1815) (Orthoptera: Acrididae), is a polyphagous pest capable of inflicting large losses in agriculture under favorable environmental and climatic conditions. Currently, control of the pest relies solely on the application of conventional insecticides that have negative effects on the environment and human safety. In the search for a more rational, environmentally acceptable approach for locust control, we have previously reported that (Z/E)-phytal (1) is a male-produced candidate sex pheromone of this acridid. This molecule, with two stereogenic centers at C-7 and C-11, has four different diastereomers along with the Z/E stereochemistry of the double bond at C-2. In this paper, we present for the first time the enantioselective synthesis of the four diastereomers of (E)-phytal and their electrophysiological and behavioral activity on males and females. Our results demonstrate that the (R,R)-phytal is the most active diastereomer in both assays, significantly attracting females in a double-choice Y olfactometer, and confirming the previous chromatographic assignment as component of the sex pheromone of the Moroccan locust.
- Guerrero, Angel,Ramos, Victoria Elena,López, Sergio,Alvarez, José María,Domínguez, Aroa,Coca-Abia, María Milagro,Bosch, María Pilar,Quero, Carmen
-
-
- Imine based chiral liquid crystals: Effect of varying the terminal substituent and orientation of ester linking unit
-
New liquid crystalline compounds composed of three-benzene-ring molecular core comprising both the imine and ester linkage units, (S)-3,7-dimethyloctyloxy chiral unit at one of terminals and n-dodecyl/dodecyloxy group as other side chain have been synthesized and characterized to study the effect of varying terminal chains, the orientation of polar ester linking group and the presence of molecular chirality on mesophase properties of imine based calamitic compounds. The liquid crystalline properties of the compounds were investigated by differential scanning calorimetry, optical polarizing microscopy and electro-optic methods. As a result of the strong effect of chirality of (S)-3,7-dimethyloctyloxy chain, all Schiff bases (imines) exhibit enantiotropic chiral smectic C (SmC*), chiral nematic (N*) as well as SmX phase just below the SmC* phase and blue phase (BP) appearing monotropically. The SmC* phase shows ferroelectric switching behaviour with PS values in the range 70–130 nC cm?2. The alteration of the n-alkyl tail with an alkoxy chain gives rise to a significant increase up to 30 °C in mesomorphic transitions. The change in the orientation of polar ester linking group has no effect on the type and sequence of observed LC phase. As compared with (S)-4-(3,7-dimethyloctyloxy)phenol based imine derivatives (7a, 7b), the chiral nematic (N*) mesophase temperature range of (S)-4-(3,7-dimethyloctyloxy)benzoate based compounds (8a, 8b) significantly broadened. Additionally, a decrease on the phase transition temperatures occurred with regardless of introducing n-dodecyl/dodecyloxy group as side chains.
- Karanl?k, Gürkan,Ocak, Hale,Bilgin Eran, Belk?z
-
p. 567 - 577
(2018/12/02)
-
- New pyridine based liquid crystalline esters with different terminal chains
-
The synthesis, structural and mesomorphic characterization of new pyridine-based methyl esters carrying a n-alkoxy chain or 3,7-Dimethyloctyloxy branched group at terminal have been presented. The liquid crystalline properties of the new pyridine-based calamitic molecules have been investigated by polarized optical microscopy and differential scanning calorimetry. New compounds exhibit enantiotropic smectic A mesophase at a variable mesomorphic range depending on alkoxy chain length and branching at terminal. The presence of a branched terminal group in chiral or racemic form gives rise to a sharply increase in mesomorphic range as well as decrease in crystallization points by preserving mesophase type.
- Karanl?k, Gürkan,Ocak, Hale,Bilgin Eran, Belk?z
-
-
- Viaticene A – An Unusual Tetraterpene Cuticular Lipid Isolated from the Springtail Hypogastrura viatica
-
The cuticles of springtails are extremely wear- and friction-resistant, super-hydrophobic, non-fouling, and self-cleaning. As such, the chemistry of the lipids covering these cuticles is of great interest as a model for biomimetic super-hydrophobic surfaces, although only few of these lipids have been structurally elucidated. Hypogastrura viatica, a surface-dwelling springtail, produces highly branched tetraterpene hydrocarbons with an unprecedented [6+2]-terpene connectivity as components of the epicuticular lipid layer. The structure of the major lipid component, viaticene A, was elucidated through isolation, spectroscopic analysis, chemical derivatization, synthesis, as well as stereochemical analysis of the core unit obtained from ozonolysis of the isolated lipid. Viaticenes A and B represent a new class of irregular tetraterpenoid natural products.
- Bello, Jan E.,Stamm, Patrick,Leinaas, Hans Petter,Schulz, Stefan
-
supporting information
p. 2158 - 2162
(2019/03/17)
-
- PIPERAZINE-CONTAINING TWO-PHOTON ABSORBING COMPOUNDS
-
A two-photon absorbing (TPA) compound is provided along with a method of making same. The TPA compound has a general structural formula: where R1 and R2 are independently selected from the group consisting of linear or branched alkyl chains having a general formula CnH2n+1, n ranges from about 6 to about 20, and ethoxylated alkyls having a general formula R3(OCH2CH2)mOCH2CH2—, where R3 is a C1 to C4 alkyl group, and where m ranges from 0 to about 3; and where Y is selected from the group consisting of H, OH, and alkoxyl groups.
- -
-
Paragraph 0044
(2018/10/19)
-
- NEAR-INFRARED ABSORPTION COMPOSITION, CURED FILM, NEAR-INFRARED CUT FILTER, SOLID-STATE IMAGING DEVICE, INFRARED SENSOR, AND COMPOUND
-
To provide a near-infrared absorption composition which contains a squarylium compound having excellent solvent solubility, a cured film which uses the near-infrared absorption composition, a near-infrared cut filter, a solid-state imaging device, an infrared sensor, and a compound. A near-infrared absorption composition includes a compound represented by the following Formula (1) and a resin. R1 and R2 each independently represent “—S1-L1-T1” or the like, R3 and R4 each independently represent a hydrogen atom or an alkyl group, X1 and X2 each independently represent an oxygen atom or —N(R5)—, R5 represents a hydrogen atom or the like, Y1 to Y4 each independently represent a substituent, p and s each independently represent an integer of 0 to 3, and q and r each independently represent an integer of 0 to 2; and S1 represents an arylene group or the like, L1 represents an alkylene group or the like, and T1 represents an alkyl group or the like.
- -
-
Paragraph 0339; 0350
(2018/01/04)
-
- Perylene bay 1,7-bit nitro-containing perylene bisimide derivative and application of perylene bisimide derivative in ammonia gas detection
-
The invention provides a perylene bay 1,7-bit nitro-containing perylene bisimide derivative. The perylene bay 1,7-bit nitro-containing perylene bisimide derivative is used for preparing a perylene bay 1,7-bit nitro-containing perylene bisimide derivative microwire, and is used for preparing a gas-sensitive element of a resistor-type gas-sensitive sensor; in the prepared gas-sensitive element, a material forming a source zone and a drain zone is simple substance gold, the material for forming a channel region is the perylene bay 1,7-bit nitro-containing perylene bisimide derivative microwire, and the material for forming a gate medium layer is silicon and silica. The gas-sensitive element used in the ammonia gas detection has the advantages that the response and recovery time is short, the detection limit is low, the resistor-type gas-sensitive sensor is simplified and minimized, the carrying is facilitated, and the effective and rapid detection of ammonia gas is achieved.
- -
-
Paragraph 0019
(2017/09/26)
-
- Oligonucleotide with protected base
-
The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.
- -
-
Page/Page column 73; 74; 75
(2016/07/27)
-
- Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1
-
Lipoxygenases metabolize polyunsaturated fatty acids into signalling molecules such as leukotrienes and lipoxins. 15-lipoxygenase-1 (15-LOX-1) is an important mammalian lipoxygenase and plays a crucial regulatory role in several respiratory diseases such as asthma, COPD and chronic bronchitis. Novel potent and selective inhibitors of 15-LOX-1 are required to explore the role of this enzyme in drug discovery. In this study we describe structure activity relationships for 6-benzyloxysalicylates as inhibitors of human 15-LOX-1. Kinetic analysis suggests competitive inhibition and the binding model of these compounds can be rationalized using molecular modelling studies. The most potent derivative 37a shows a Ki value of 1.7 μM. These structure activity relationships provide a basis to design improved inhibitors and to explore 15-LOX-1 as a drug target.
- Eleftheriadis, Nikolaos,Thee, Stephanie,Te Biesebeek, Johan,Van Der Wouden, Petra,Baas, Bert-Jan,Dekker, Frank J.
-
p. 265 - 275
(2015/03/30)
-
- Dipole-Moment-Driven Cooperative Supramolecular Polymerization
-
While the mechanism of self-assembly of π-conjugated molecules has been well studied to gain control over the structure and functionality of supramolecular polymers, the intermolecular interactions underpinning it are poorly understood. Here, we study the mechanism of self-assembly of perylene bisimide derivatives possessing dipolar carbonate groups as linkers. It was observed that the combination of carbonate linkers and cholesterol/dihydrocholesterol self-assembling moieties led to a cooperative mechanism of self-assembly. Atomistic molecular dynamics simulations of an assembly in explicit solvent strongly suggest that the dipole-dipole interaction between the carbonate groups imparts a macro-dipolar character to the assembly. This is confirmed experimentally through the observation of a significant polarization in the bulk phase for molecules following a cooperative mechanism. The cooperativity is attributed to the presence of dipole-dipole interaction in the assembly. Thus, anisotropic long-range intermolecular interactions such as dipole-dipole interaction can serve as a way to obtain cooperative self-assembly and aid in rationalizing and predicting the mechanisms in various synthetic supramolecular polymers. (Graph Presented).
- Kulkarni, Chidambar,Bejagam, Karteek K.,Senanayak, Satyaprasad P.,Narayan,Balasubramanian,George, Subi J.
-
supporting information
p. 3924 - 3932
(2015/04/14)
-
- Hydromethylation of Unactivated Olefins
-
A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or to directly "edit" complex natural products and other advanced materials. The method is also amenable to the simple installation of radioactive and stable labeled methyl groups.
- Dao, Hai T.,Li, Chao,Michaudel, Quentin,Maxwell, Brad D.,Baran, Phil S.
-
supporting information
p. 8046 - 8049
(2015/07/15)
-
- Selective recovery of a pyridine derivative from an aqueous waste stream containing acetic acid and succinonitrile with solvent impregnated resins
-
Solvent impregnated resins (SIRs) were evaluated for the recovery of pyridine derivatives from an aqueous waste-stream containing also acetic acid and succinonitrile. For this purpose, a new solvent was developed, synthesized and impregnated in Amberlite XAD4. Sorption studies were used to determine the capacity, selectivity and the mass-transfer rate. A high capacity of 21 g 4-cyanopyridine (CP) per kg SIR was found, with very high selectivity toward CP over the other solutes of at least 570. A modified Langmuir equation could describe the equilibrium sorption isotherm. Both the linear driving force model and a Fickian diffusion model were evaluated. The Fick-model described both regeneration and loading best. The CP-diffusivity through the solvent phase was estimated at 6.53 · 10-13 ± 2.5% m2 s-1. The model was validated using fixed-bed column experiments. The R2 values for this model ranged between 0.94 at a flow rate of 5 mL/min and 0.99 at a flow rate of 1 mL/min during the loading cycle. Due to mass-transfer limitations the breakthrough profiles were broad and breakthrough occurred after 5 or 23 bed volumes, for flow rates of 5 and 1 mL/min, respectively. Both acetic acid and succinonitrile broke through immediately due to the very high CP-selectivity of the SIR.
- Bokhove,Visser,Schuur,De Haan
-
-
- BASE-PROTECTED OLIGONUCLEOTIDE
-
The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3'-position.
- -
-
Paragraph 0352
(2015/01/18)
-
- Cu-Catalyzed cascades to carbocycles: Union of diaryliodonium salts with alkenes or alkynes exploiting remote carbocations
-
Copper-catalyzed cascade reactions between alkenes or alkynes and diaryliodonium salts form carbocyclic products in a single step. Arylation of the unsaturated functional group is proposed to form a carbocation intermediate that facilitates hydride shift pathways to translocate the positive charge to a remote position and enables ring formation via a Friedel-Crafts-type reaction.
- Zhang, Fengzhi,Das, Shoubhik,Walkinshaw, Andrew J.,Casitas, Alicia,Taylor, Michael,Suero, Marcos G.,Gaunt, Matthew J.
-
supporting information
p. 8851 - 8854
(2014/07/08)
-
- H-bonded complexes containing 1,3,4-oxadiazole derivatives: Mesomorphic behaviour, photophysical properties and chiral photoinduction
-
Two series of new V-shaped acids derived from 1,3,4-oxadiazoles are described. These acids were used to prepare supramolecular complexes through hydrogen bonding with 2,4-diamino-6-dodecylamino-1,3,5-triazine in a 3:1 ratio, respectively. The formation of the complexes was studied by infrared and NMR techniques. The thermal behaviour and mesomorphic properties of all the complexes were investigated by polarized light optical microscopy, differential scanning calorimetry and X-ray diffraction. Hexagonal and rectangular columnar mesophases were observed for all complexes at room temperature, without evidence of crystallization. The results of circular dichroism studies allowed us to propose that in the liquid crystalline state these materials adopt a helical columnar organization and this chirality can be controlled by irradiation with CPL. Furthermore, the complexes display strong blue luminescence in solution and in the mesophase. the Partner Organisations 2014.
- Vieira, Andre A.,Cavero, Emma,Romero, Pilar,Gallardo, Hugo,Serrano, Jose Luis,Sierra, Teresa
-
supporting information
p. 7029 - 7038
(2014/08/18)
-
- OLIGONUCLEOTIDE WITH PROTECTED BASE
-
The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.
- -
-
Page/Page column
(2013/10/22)
-
- TRIALKYL CATIONIC LIPIDS AND METHODS OF USE THEREOF
-
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.
- -
-
Page/Page column 115; 116; 141; 142
(2013/09/12)
-
- Two-photon absorbing arylamine-endcapped and dialkylfluorene-bridged benzobisthiazole compounds with high oleophilicity
-
Two-photon absorbing arylamine-endcapped and dialkylfluorene-bridged benzobisthiazole-based compounds are provided. These two-photon absorbing benzobisthiazole-based compounds show high solubility in nonpolar hydrocarbon solvents (oleophilicity) and high two-photon properties, especially in the nanosecond domain of pulse-laser excitation.
- -
-
Page/Page column 9; 10
(2013/06/28)
-
- New chiral discotics with helical organization of the mesophase - Liquid crystalline derivatives of dibenzotetraaza[14]annulene
-
Two optically pure derivatives of dibenzotetraaza[14]annulene, bearing four (S)- or (R)- 3,7-dimethyloctoxy peripheral chiral tails, respectively, and two hydroxybenzoyl meso substituents were synthesized using a convergent multi-step route. The structure of the products was determined by 1H and 13C NMR spectroscopy, ESI-MS, and elemental analysis. The mesomorphic behavior of the two chiral compounds, deciphered by differential scanning calorimetry (DSC), small-angle X-ray diffractometry (SA-XRD), and polarizing optical microscopy (POM) investigations, revealed the induction of two lamello-columnar phases, i.e., columnar stacks confined in smectic layers, whose columns may be arranged either according to the pg rectangular planar symmetry (for the low-temperature phase) or without registry between vicinal layers (for the high-temperature mesophase). Evidence of a helical organization of the molecules in the mesophases was obtained using a combination of electronic circular dichroism (ECD) and SA-XRD results, Molecular Dynamics simulations and quantum-chemical calculations.
- Grolik, Jaros?aw,Dudek, ?ukasz,Eilmes, Julita,Eilmes, Andrzej,Górecki, Marcin,Frelek, Jadwiga,Heinrich, Beno?t,Donnio, Bertrand
-
p. 3875 - 3884
(2012/07/14)
-
- A linear conjugated core for functional columnar liquid crystals
-
Two series of polycatenar molecules consisting of a π-conjugated rigid core derived from 3-hexen-1,5-diyne coupled to different types of benzoic acid derivatives have been prepared and their potential as multifunctional materials has been investigated. The size ratio between the rigid core and the benzoate-derived groups, which vary in bulk, is crucial to address self-organization, thus indicating the delicate balance of forces involved in liquid crystalline (LC) behaviour. LC nematic, crystalline or LC columnar behaviour is observed depending on the structure of the benzoate moiety. Hexagonal two-dimensional columnar organization is attained for mesogens with benzoate-derived groups bearing six and nine alkoxylic tails. The stacking unit of the columnar organizations is different depending on the total number of tails, twelve or eighteen, with two molecules and half a molecule per columnar stratum, respectively. Macroscopic properties related to molecular structure, such as luminescence, chirality and electroactivity, have also been studied. Luminescent behaviour is observed for all mesogenic materials, which show higher Stokes shifts than in solution. In addition, supramolecular chirality in the mesophase has been observed for a chiral mesogen. Finally, the photoconducting behaviour of two of the columnar materials has been evaluated. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012.
- Perez, Ana,Serrano, Jose Luis,Sierra, Teresa,Ballesteros, Alfredo,Saa, Diana De,Termine, Roberto,Pandey, Upendra Kumar,Golemme, Attilio
-
supporting information; experimental part
p. 830 - 842
(2012/05/04)
-
- Two-photon absorption properties of proquinoidal D-A-D and A-D-A quadrupolar chromophores
-
We report the synthesis, one- and two-photon absorption spectroscopy, fluorescence, and electrochemical properties of a series of quadrupolar molecules that feature proquinoidal p-aromatic acceptors. These quadrupolar molecules possess either donoracceptor donor (D-A-D) or acceptordonoracceptor (A-D-A) electronic motifs, and feature 4-N,N-dihexylaminophenyl, 4-dodecyloxyphenyl, 4-(N,N-dihexylamino)benzo[c][1,2,5]thiadiazolyl or 2,5-dioctyloxyphenyl electron donor moieties and benzo[c][1,2,5]thiadiazole (BTD) or 6,7-bis(30,70-dimethyloctyl)[1,2,5]thiadiazolo[3,4-g]quinoxaline (TDQ) electron acceptor units. These conjugated structures are highly emissive in nonpolar solvents and exhibit large spectral red-shifts of their respective lowest energy absorption bands relative to analogous reference compounds that incorporate phenylene components in place of BTD and TDQ moieties. BTD-based D-A-D and A-D-A chromophores exhibit increasing fluorescence emission redshifts, and a concomitant decrease of the fluorescence quantum yield (Ff) with increasing solvent polarity; these data indicate that electronic excitation augments benzothiadiazole electron density via an internal charge transfer mechanism. The BTD- and TDQcontaining structures exhibit blue-shifted two-photon absorption (TPA) spectra relative to their corresponding one-photon absorption (OPA) spectra, and display high TPA cross sections (>100 GM) within these spectral windows. D-A-D and A-D-A structures that feature more extensive conjugation within this series of compounds exhibit larger TPA cross sections consistent with computational simulation. Factors governing TPA properties of these quadrupolar chromophores are discussed within the context of a three-state model.
- Susumu, Kimihiro,Fisher, Jonathan A.N.,Zheng, Jieru,Beratan, David N.,Yodh, Arjun G.,Therien, Michael J.
-
scheme or table
p. 5525 - 5539
(2011/08/06)
-
- Chiral induction by helical neighbour: Spectroscopic visualization of macroscopic-interaction among self-sorted donor and acceptor π-stacks
-
Supramolecular induction of chirality to a π-stacked dialkoxynaphthalene (DAN)-fiber (made of achiral building blocks) from a neighbouring helical naphthalenediimide (NDI)-fiber is reported. CD-studies helped in understanding the nature of co-assembly in the donor-acceptor chromophore mixture from molecular to macroscopic scale.
- Molla, Mijanur Rahaman,Das, Anindita,Ghosh, Suhrit
-
supporting information; experimental part
p. 8934 - 8936
(2011/10/01)
-
- Orthogonal action of noncovalent interactions for photoresponsive chiral columnar assemblies
-
(Figure Presented) Making a stack: Helical columnar architectures are prepared by a hierarchical self-assembly process involving H-bonding, π-π, and ion-dipole interactions (see picture). The strategic combination of these supramolecular interactions within mesomorphic systems yields materials in which photoinduced chirality and the incorporation of ions can be used to design multifunctional liquid crystals.
- Vera, Francisco,Barbera, Joaquin,Romero, Pilar,Serrano, Jose Luis,Ros, M. Blanca,Sierra, Teresa
-
experimental part
p. 4910 - 4914
(2010/09/15)
-
- Self-assembly in helical columnar mesophases and luminescence of chiral 1H-pyrazoles
-
Chiral polycatenar lH-pyrazoles self-assemble to form columnar mesophases that are stable at room temperature. X-ray diffraction and CD studies in the mesophase indicate a supramolecular helical organization consisting of stacked H-bonded dimers. The liquid-crystalline compounds reported are 3,5-bis(dialkoxyphenyl)-1Hpyrazoles that incorporate two or four dihydrocitronellyl chiral tails. It can be observed that the grafting of these branched chiral substituents onto the 3,5-diphenyl-1H-pyrazole core has a beneficial role in inducing mesomorphism, because isomeric linear-chain compounds are not liquid crystalline; this is not the usual scheme of behav-ior. Furthermore, the molecular chirality is transferred to the columnar mesophase, because preferential helical arrangements are observed. Films of the compounds are luminescent at room temperature and constitute an example of the self-organization of nondiscoid units into columnar liquid-crystalline assemblies in which the functional molecular unit transfers its properties to a hierarchically built superstructure.
- Beltran, Eduardo,Cavero, Emma,Barbera, Joaquin,Serrano, Jose Luis,Elduque, Anabel,Gimenez, Raquel
-
experimental part
p. 9017 - 9023
(2010/04/05)
-
- Tris(N-salicylideneanilines) [TSANs] exhibiting a room temperature columnar mesophase: synthesis and characterization
-
Tris(N-salicylideneaniline) derivatives with peripheral branched alkyl chains, existing in their C3h and Cs symmetric keto-enamine tautomeric forms, synthesized by condensing alkoxyanilines with 1,3,5-triformylphloroglucinol, display a technologically important columnar liquid crystal phase over a wide thermal interval (~160 °C) well below and above room temperature, as established by optical and calorimetric studies.
- Yelamaggad,Achalkumar
-
p. 7071 - 7075
(2007/10/03)
-
- Synthesis of optically active amphiphilic tetrathiafulvalene derivatives
-
The synthesis and characterization of novel chiral tetrathiafulvalenes bearing two long alkyl chains at one end of the π-electron rich unit and different functional groups - ester, acid or thiolate - at the other extreme is described. The synthetic method requires the preparation of 1,3-dithiol derivatives with two stereogenic centers. Different routes and reaction conditions were explored to form these compounds, whose optimized synthesis involved the nucleophilic substitution of a chiral bromo methylene derivative with tetrabutylammonium bis(2-thioxo-1,3-dithiole-4,5-dithiolate)zincate. The tetrathiafulvalenes were prepared by coupling the 1,3-dithiol derivative with 4,5-bis(methoxycarbonyl)-1,3-dithiol-2-one or 4,5-bis(2-cyanotehylthio)-1,3- dithiol-2-thione. The products were fully characterized, including by circular dichroism spectroscopy, which confirmed their optical activity. They are promising candidates to be used as building blocks in supramolecular materials for molecular electronics, to produce systems with unique electrical, magnetic or optical properties that stem from their chirality.
- Gomar-Nadal, Elba,Rovira, Concepció,Amabilino, David B.
-
p. 3370 - 3379
(2007/10/03)
-
- Discotic liquid crystalline materials for potential nonlinear optical applications: Synthesis and liquid crystalline behavior of 1,3,5-triphenyl-2,4, 6-triazine derivatives containing achiral and chiral alkyl chains at the periphery
-
As a novel approach to nonlinear optical materials, new octupolar discotic liquid crystalline materials 1,3,5-triphenyl-2,4,6-triazine derivatives containing achiral alkyl chains (5a) and chiral alkyl chains (5b) at the periphery were synthesized. The former exhibits an ordered hexagonal columnar mesophase, whereas the latter displays a rectangular columnar mesophase. The negative exciton splitting observed in the CD spectrum of a thin film of 5b suggests that it has a left-handed helical structure within the column.
- Lee, Hyoyoung,Kim, Dongwoo,Lee, Hyung-Kun,Qiu, Wenfeng,Oh, Nam-Keun,Zin, Wang-Cheol,Kim, Kimoon
-
p. 1019 - 1022
(2007/10/03)
-
- New terpene hydrocarbons from the alligatoridae (crocodylia, reptilia)
-
The contents of the paracloacal gland secretions of the alligatorids Alligator mississippiensis, A. sinensis, Paleosuchus palpebrosus, and P. trigonatus were investigated. Novel acyclic hydrocarbon terpenes with a rare trisubstituted 2,4-diene system were identified in the secretions of A. sinensis, P. palpebrosus, and P. trigonatus. The structures of the monoterpene (2E,4E)-3,7-dimethyl-2,4-octadiene (9) and the sesquiterpene (2E,4E,7S)-3,7,11-trimethyl-2,4-dodecadiene (14) were proven by synthesis and gas chromatography on a chiral phase. Several other new terpenes (11, 16, 17, 18, 19, and 20) related to these components also were present in the secretions, as well as the known compounds myrcene (6), (E)-β-farnesene (4), (E)-β-springene (3), squalene (5), cembrene A (1), and 11,12-dihydrocembren-10-one (2).
- Schulz, Stefan,Krueckert, Karsten,Weldon, Paul J.
-
-
- Novel High Energy Intermediate Analogues with Triazasterol-Related Structures as Inhibitors of Ergosterol Biosynthesis. Part I: Synthesis and Antifungal Activity of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2-Substituted 2-Imidazolinamines
-
A series of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2- and N2,4-substituted imidazolin-2-amine hydrochlorides with triazasterol-related structures was designed and synthesized as stable analogues to mimic high energy intermediates of ergosterol biosynthesis. The in vivo antifungal susceptibility tests with a standard panel of pathogenic fungi revealed moderate to strong antimycotic effects of the sixteen prepared compounds, in some cases comparable with the activity observed for itraconazole.
- Goessnitzer, Edith,Malli, Roland,Schuster, Silvia,Favre, Bertrand,Ryder, Neil S.
-
p. 535 - 546
(2007/10/03)
-
- Computing handedness: Quantized and superposed switch and dynamic memory of helical polysilylene
-
Two new conjugating helical polymers comprising a rodlike silicon backbone and enantiopure chiral pendants, poly{(R)-3,7-dimethyloctyl-(S)-3-methylpentylsilylene} (PS-1) and its diastereomeric poly{(S)-3,7-dimethyloctyl-(S)-3-methylpentylsilylene} (PS-2), were prepared. Molecular mechanics calculations of PS-1 and PS-2 model oligomers indicated a double well potential energy curve corresponding to almost enantiomeric helices with dihedral angles of 150-160° (P-motif, global minimum) and 200-210° (M-motif), regardless of their tacticity. Experimentally, it was found that PS-1 in dilute isooctane revealed switchable ambidextrous helicity on application of a thermal energy bias. Although PS-1 featured three distinct switching regions, viz. "region 1, between -80 and -10 °C", "region 2, between -10 and +10 °C", and "region 3, between +10 °C and +80 °C", the switching properties were interpreted as the result of superposed P- and M-helicities, undergoing dynamic pseudo-racemization or oscillation. Oscillating helicity in region 2 was roughly estimated to be about 13 cm-1. The superposed helicity in region 2 was critical since it afforded molecular recognition ability with a dynamic memory function that was highly susceptible to solvent molecular topology and volume fraction. This could lead to potential as a molecular information processor to serve as a gauge of chemical properties. On the other hand, PS-2 could not switch its preferential screw-sense in the range of -80 to +80 °C. This may be related to greater differences the potential energy curve between P- and M-motifs.
- Fujiki,Koe,Motonaga,Nakashima,Terao,Teramoto
-
p. 6253 - 6261
(2007/10/03)
-
- Synthesis and effect of two new penetration enhancers on the transdermal delivery of 5-fluorouracil through excised rat skin
-
The tetrahydrogeraniol (THG) derivative, ethyl-(3,7-dimethyl octyl thio) acetate (EDOTA) was prepared by reacting tetrahydrogeranyl bromide (obtained by reaction of 40% hydrobromic acid and concentrated sulfuric acid) with ethyl 2-mercaptoacetate, while 3,7-dimethyl octyl propionate (DOP) was synthesized by a common esterification reaction by reacting THG with propionic acid in the presence of cyclohexane and concentrated sulfuric acid. The penetration-enhancing effect of the new enhancers were compared with THG and Azone in vitro using excised rat skin in modified Franz-type diffusion cells. 5-Fluorouracil (5-FU), a hydrophilic drug with poor skin permeability was used as a model permeant. Skin samples were pretreated with pure liquid enhancers for 12 h. 5-FU flux through the control and enhancer-treated skin increased linearly with its concentration in the receptor compartment. EDOTA and DOP interacted with the skin rapidly (2 h), and the duration of action is at least 24 h. Significant differences were found in the flux values of 5- FU; EDOTA and DOP enhanced the permeability of the drug about 6-fold and 11- fold respectively. Increased partition coefficient and diffusion coefficient values were obtained by these enhancers. The results suggested that the amount of EDOTA and DOP in the skin, especially in the stratum corneum, may be related to their penetration-enhancing effect.
- Hanif, Raja Muhammad,Qineng, Ping,Fenzhu, Muo
-
p. 1428 - 1431
(2007/10/03)
-
- Polypeptide compound and a process for preparation thereof
-
A polypeptide compound having antimicrobial activity of the following general formula: STR1 wherein R1 is hydrogen or acyl group, R2 is hydroxy or acyloxy, R3 is hydroxysulfonyloxy, and R4 is hydrogen or carbamoyl, with proviso that R1 is not palmitoyl, when R2 is hydroxy, R3 is hydroxysulfonyloxy and R4 is carbamoyl, and a pharmaceutically acceptable salt thereof.
- -
-
-
- Peripherically Octasubstituted Phthalocyanines with Branched Alkoxy Chains
-
Phthalocyanines (H2Pc) octasubstituted with branched alkoxy chains were synthesized: 2,3,9,10,16,17,23,24-octakis(3,7-dimethyloctoxy)phthalocyanine (1a) and 2,3,9,10,16,17,23,24-octakis(3,7,11-trimethyldodecoxy)phthalocyanine (1b).Their mesomorphic properties were studied by DSC, polarization microscopy and X-ray diffraction.Compound 1a, which was initially crystalline at room temperature, maintains its mesomorphic structure on cooling back to room temperature.Compound 1b is mesomorphic at room temperature.It shows a Dho -> Dhd transition at 34 deg C and a transition of unknown nature at 173 deg C.Both compounds display a D -> I transition.Keywords: discotic liquid crystals, columnar mesophase, phthalocyanine
- Schouten, P. G.,Pol, J. F. van der,Zwikker, J. W.,Drenth, W.,Picken, S. J.
-
p. 291 - 305
(2007/10/02)
-