New ketone homoenolate anion equivalents derived from (alkenyl)pentamethyl phosphoric triamides
Lithiated ambident anions derived from (1-alkyl-2-propenyl)- or (1-phenyl-2-propenyl)-pentamethyl phosphoric triamides undergo regioselectively γ-reaction with various alkylating reagents and isobutyraldehyde. Further hydrolysis of adducts releases the ketone under acid conditions. Number of synthetic applications clearly show the ketone homoenolate behaviour of these new carbanions.
Grison, Claude,Thomas, Antoine,Coutrot, Frédéric,Coutrot, Philippe
p. 2101 - 2123
(2007/10/03)
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