- One-pot solvent-free reductive amination with a solid ammonium carbamate salt from CO2 and amine
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Many amines are liquid and their handling is inconvenient compared with the corresponding solids. We transformed a liquid (S)-(-)-1-phenylethylamine 1 to the corresponding neutral solid form 2 by reacting with carbon dioxide. We performed reductive aminat
- Kang, Philjun,Lee, Kyu Myung,Lee, Won Koo,Lee, Kyu Hyung,Lee, Byeongno,Cho, Jaeheung,Hur, Nam Hwi
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p. 46203 - 46207
(2015/02/19)
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- Synthesis of chiral C2-symmetric 1,2-diamines by the addition of organolithium reagents to N,N'-bis[(S)-1-phenylethyl]ethanediimine
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The additions of alkyl-, phenyl- and vinyllithium reagents to N,N'-bis[(S)-1-phenylethyl]ethanediimine in THF at -78°C and in DME at -60°C gave high yields of 1,2-diamines with low stereocontrol. Care was taken to quench the reaction mixtures with de-aera
- Martelli, Gianluca,Morri, Stefano,Savoia, Diego
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p. 8367 - 8374
(2007/10/03)
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- Synthesis, enzymic degradation, lipophilic properties, and biological activity of [D-alanine2, t-butylglycine 5]enkephalin amide
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L-C(a)-t-Butylglycine (Bug), its amide, methyl ester, and N(a)-t-butoxycarbonyl derivative were prepared by an asymmetric synthesis, and the Hansch side-chain hydrophobic (lipophilicity) parameter determined. A new enkephalin analogue, H . Tyr-D-Ala-Gly-Phe-Bug . HN2 was synthesized which is pharmacologically active in two in vitro assays and strongly resistant against a number of enzymes in vitro.
- Fauchere,Petermann
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p. 824 - 831
(2007/10/02)
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