Microscopic protonation constants in tobramycin. An NMR and pH study with the aid of partially N-acetylated derivatives
Three tetra-N-acetyl derivatives and one tri-N-acetyl derivative of tobramycin (1) have been prepared by partial N-acetylation.Comparison of the pKa values, determined by NMR chemical shift titrations and pH titration of the derivatives, with t
Szilagyi, Laszlo,Pusztahelyi, Zita Sz.,Jakab, Sandor,Kovacs, Imre