Preparation method of almotriptan key intermediate 1-(4-amino-phenylmethylsulfonyl)pyrrolidine
The invention discloses a preparation method of an almotriptan key intermediate 1-(4-amino-phenylmethylsulfonyl)pyrrolidine. The main steps comprise: 1) preparing a Vilsmeier reagent by using BTC andDMF, and carrying out a sulfonylation reaction on p-nitr
AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON
The invention relates to certain aminopyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).
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Page/Page column 125
(2011/05/05)
PREPARATION AND UTILITY OF SUBSTITUTED INDOLES
Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.
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Page/Page column 38-39
(2008/06/13)
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