Synthesis of 2-methylidene-1-silacyclohexanes from 2,6-dibromohex-1-ene and polyhalosilanes
Various 2-methylidene-1-silacyclohexanes were prepared by straightforward syntheses from readily available polychloro- or polyfluorosilanes, magnesium and 2,6-dibromohex-1-ene using Barbier-type conditions or a previously synthesized Grignard reagent. Good yields were obtained considering the low stability of the products in the reaction conditions.
Díez-González, Silvia,Blanco, Luis
p. 5531 - 5539
(2007/10/03)
Packing for use in resolution
The packing for use in resolution proposed for the liquid chromatography for particularly the opti-cal resolution of racemic compounds is prepared by reacting a silica gel carrier with a so-called silane treating agent to introduce a spacer part therein and chemically bonding it with a copper salt of a carboxylic or thiocarboxylic acid selected from the group consisting of optically active D- and L-2--acetizinecaroxylic acid, proline, hydroxyproline and allohydroxyproline. The steric bulkiness, the distance between the silica gel and the optically active group and the degree of hydrophobicity are specified so as to obtain an excellent resolving power.
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(2008/06/13)
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