Direct transformation of arylpropynes to acrylamides via a three-step tandem reaction
A novel and metal-free acrylamides formation between arylpropynes and hydroxylamine hydrochloride through sp3 C-H and C-C bond cleavage has been achieved with DDQ as an oxidant. The mechanistic study shows that the acrylamides are formed through a three-step tandem sequence, including cross-dehydrogenative-coupling (CDC) reaction, aza-Meyer-Schuster rearrangement and Beckmann rearrangement. This journal is The Royal Society of Chemistry 2014.
Qiu, Jun,Zhang, Ronghua
supporting information
p. 1556 - 1560
(2014/03/21)
Iron-catalyzed C-H and C-C bond cleavage: A direct approach to amides from simple hydrocarbons
Something functional: The title reaction proceeds in the presence of azide and water to deliver amides in high yields, and it can be used in a ring-expansion strategy to generate lactams. A mechanism is proposed based on experimental results. This reaction offers a new approach to functionalizing simple and readily available hydrocarbons. DDQ=2,3-dichloro-5,6-dicyano-1,4- benzoquinone. Copyright
Qin, Chong,Zhou, Wang,Chen, Feng,Ou, Yang,Jiao, Ning
supporting information; experimental part
p. 12595 - 12599
(2012/01/15)
Stereoselective synthesis of (2E)-cinnamanilides via desulfonylation of (2E)-α-amino-α,β-unsaturated sulfones by samarium/glacial acetic acid/ethanol system
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Liu, Yunkui,Zhang, Yongmin
p. 372 - 375
(2007/10/03)
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