- Phenyl and pyridyl LTA4H modulators
-
Leukotriene A4 hydrolase (LTA4H) inhibitors, compositions containing them, and methods of use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and inflammatory conditions.
- -
-
Page/Page column 29
(2010/11/24)
-
- PYRIMIDINE DERIVATIVES
-
The present invention provides a pyrimidine derivative represented by Formula (I) [wherein Ar represents substituted or unsubstituted aryl, etc., R1 represents -NR2R3 (wherein R2 represents a hydrogen atom or su
- -
-
Page/Page column 33
(2010/02/14)
-
- Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors
-
The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-4(Z)- (methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors.
- Ting, Pauline C,Lee, Joe F,Anthes, John C,Shih, Neng-Yang,Piwinski, John J
-
p. 491 - 494
(2007/10/03)
-