- Method for producing halogen-substituted aromatic aldehyde
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In the production method of the invention, a halogen-substituted aromatic compound is reacted with carbon monoxide in the presence of hydrogen fluoride and boron trifluoride into a corresponding halogen-substituted aromatic aldehyde. By the use of hydrogen fluoride and boron trifluoride, the para position to halogen atom is selectively formylated to provide the halogen-substituted aromatic aldehyde in high yields in a short reaction time even at temperatures lower than room temperature.
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Page/Page column 6
(2008/06/13)
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- Sulfonamide compounds and medicinal use thereof
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A sulfonamide compound of the formula (I):R 1 --SO 2 NHCO--A--R 2 (I)wherein R 1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R 2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.
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- IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF
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Imidazole compounds represented by general formula (I): wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided. These compounds are useful in treating the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy inhibitory action.
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- Imidazole derivatives, compositions and use
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Compounds of the formula: STR1 wherein R is (Hal)m wherein Hal represents a halogen atom and m is 1 or 2, or R is-(B1)n1 W1 wherein B1, n1 and W1 are as defined below; W and (when present) W1, which may be the same or different, each represents a carboxyl, esterified carboxyl, amide, N-C1-4 alkyl-amide, N,N-di-(C1-4 alkyl)-amide, nitrile, aldehyde, amino, hydroxymethyl, or tetrazolyl group; n and (when present) n1 which may be the same or different, are each 0 or 1; and A, B and (when present) B1, which may be the same or different, each represents a straight chain or branched C1-3 alkylene or C2-3 alkenylene group. These compounds have been found to possess potent and selective inhibitory activity against thromboxane synthetase which renders the compounds useful in the treatment or prophylaxis of thrombo-embolic disorders.
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- THE OXIDATION OF ALDEHYDES TO ACIDS WITH CALCIUM HYPOCHLORITE
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Calcium hypochlorite is an efficient reagent for the oxidation of aldehydes to the corresponding acids.Reactions are carried out at ambient temperature in aqueous acetonitrile-acetic acid solution.Aliphatic aldehydes and aromatic aldehydes with electron withdrawing groups afford good to excellent yields.Nuclear chlorination is the preferred reaction in aromatic aldehydes with electron donating groups.
- Nwaukwa, Stephen O.,Keehn, Philip M.
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p. 3131 - 3134
(2007/10/02)
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