- Preparation method of quininone derivative
-
The invention provides a preparation method of a quininone derivative, and belongs to the field of pharmaceutical chemical industry. According to the method disclosed by the invention, the 3-quininonederivative is obtained by taking a diethanolamine derivative as a starting material through chlorination or methanesulfonic acid and diethyl malonate cyclization and Dieckmann Condensation. The product produced by the method has the characteristics of high purity, high yield, low cost, simple operation and stable process.
- -
-
Paragraph 0047-0050
(2020/04/06)
-
- Preparation method of optical activity 3-quinuclidinol
-
The invention relates to an intermediate synthesis method, belongs to the field of organic synthesis, and particularly relates to a preparation method of optical activity 3-quinuclidinol with the advantages that the operation is simple and convenient, the cost is low, and the method is suitable for industrial production. An intermediate of 3-quinuclidinol is obtained by using 4-nipecotic acid as astarting material through esterification, nucleophilic substitution, Dieckmann condensation, decarboxylation, salification, reduction, acetylization, chemical resolution and the like. The reaction formula is shown in the description.
- -
-
Paragraph 0011; 0012
(2018/04/03)
-