Efficient construction of C=N double bonds via acceptorless dehydrogenative coupling
The efficient construction of C=N double bonds has been achieved by the Ir-catalyzed intramolecular acceptorless dehydrogenative cross-coupling of tertiary amines and amides. An iridium/2-hydroxypyridine complex was identified as the highly efficient catalyst. A number of quinazolinone derivatives was prepared in excellent yields. An iridium-mediated C-H activation mechanism is proposed. This finding provides an unprecedented strategy for the direct imidation of sp3 C-H bonds.
Sun, Xiang,Hu, Yu,Nie, Shao-Zhen,Yan, Yun-Yun,Zhang, Xue-Jing,Yan, Ming
p. 2179 - 2184
(2013/10/01)
Cyclodehydrogenation of aniline derivatives carrying carboxamide or urea functions
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Moehrle,Hemmerling
p. 586 - 594
(2007/10/04)
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