Synthesis and antimicrobial evaluation of some halcones and their derived pyrazoles, pyrazolines, isoxazolines, and 5,6-dihydropyrimidine-2-(1H)-thiones
Chalcones were synthesized by a base catalyzed Claisen-Schmidt condensation reaction. Bromination of chalcones afforded the dibromo derivatives. Monobromo derivatives could be obtained by treating the corresponding dibromochalcones with dry benzene in the
Abdel-Rahman, Adel A.-H.,Abdel-Megied, Ahmed E.-S.,Hawata, Mohamed A. M.,Kasem, Eman R.,Shabaan, Mohamed T.
In vitro antimicrobial activity and in silico activity of 1-thiocarbamoyl substituted pyrazole derivatives
A convenient synthesis of 1-thiocarbamoyl-3-phenyl-5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives (2a-2g) was carried out by the condensation reaction of (E)-3-(phenyl)-1-(biphenyl-2-yl)-3-arylprop-2-en-1-ones (1a-1g) with thiosemicarbazide, sodium hydr