- Synthesis of Cinnamides via Amidation Reaction of Cinnamic Acids with Tetraalkylthiuram Disulfides Under Simple Condition
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A facile and efficient methodology for the synthesis of cinnamides has been achieved under metal- and additive-free conditions. This method allows the efficient C–N cross-coupling of diverse cinnamic acids with tetraalkylthiuram disulfides through a simply mixing operation in 1,2-dichloroethane at 100 °C. The protocol provides a direct approach to cinnamides and is featured with readily available starting materials and broad substrate scope, which shows its practical synthetic value in organic synthesis.
- Lai, Miao,Wu, Zhiyong,Su, Fangyao,Yu, Yujian,Jing, Yanqiu,Kong, Jinmin,Wang, Zhenteng,Wang, Shuai,Zhao, Mingqin
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p. 198 - 208
(2020/01/22)
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- Preparation method of cinnamamide (by machine translation)
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The synthesis system disclosed by the invention has the advantages of simple :(1) reaction conditions, wide, reaction conditions, reaction conditions, wide ;(2) substrate range, high yield (1) and wide application range, and the reaction liquid, can be used as an anti-cancer drug, anti-anti-tumor and spice precursor compound in an organic solvent to prepare a corresponding cinnamide compound, product cinnamide . The synthesis system disclosed by the invention has a broad spectrum . The synthesis system disclosed by the invention has a broad spectrum of biological activity, and is suitable for popularization and application, in the following steps, synthesizing cinnamic acid and thiuram disulfide as a raw material, in an organic, solvent, and purifying, parts by mass, separation and purification of the obtained reaction, solution in an organic solvent. (by machine translation)
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Paragraph 0057-0063
(2020/05/01)
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- Visible-light-promoted oxidation/condensation of benzyl alcohols with dialkylacetamides to cinnamides
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Oxidative cross-coupling reactions of benzyl alcohols with N,N-dialkylacetamides were developed only employing oxygen as the terminal oxidant, efficiently providing a new, novel protocol for the construction of multifunctionalized cinnamides with the synergistic effects of KOH, organic photocatalyst eosin Y, and visible light irradiation at room temperature. A broad substrate scope and mild reaction conditions are the prominent features of this transformation.
- Yang, Tianlong,Lu, Maojian,Lin, Zhaowei,Huang, Mingqiang,Cai, Shunyou
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supporting information
p. 449 - 453
(2019/01/24)
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- Chemoselective α,β-Dehydrogenation of Saturated Amides
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We report a method for the selective α,β-dehydrogenation of amides in the presence of other carbonyl moieties under mild conditions. Our strategy relies on electrophilic activation coupled to in situ selective selenium-mediated dehydrogenation. The α,β-unsaturated products were obtained in moderate to excellent yields, and their synthetic versatility was demonstrated by a range of transformations. Mechanistic experiments suggest formation of an electrophilic SeIV species.
- Teskey, Christopher J.,Adler, Pauline,Gon?alves, Carlos R.,Maulide, Nuno
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p. 447 - 451
(2019/01/04)
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- Oxidative coupling of alkenes with amides using peroxides: Selective amide C(sp3)-H versus C(sp2)-H functionalization
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A new oxidative coupling of unactivated terminal alkenes with amides using peroxides is described, in which mono- and difunctionalization of alkenes are selectively achieved. In this reaction with amides, the chemoselectivity toward the functionalization of the C(sp3)-H bonds adjacent to the nitrogen atom or the functionalization of the carbonyl C(sp2)-H bonds across alkenes relies on the reaction conditions. This journal is
- Yang, Xu-Heng,Wei, Wen-Ting,Li, Hai-Bing,Song, Ren-Jie,Li, Jin-Heng
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supporting information
p. 12867 - 12869
(2014/12/11)
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- Copper-catalyzed oxidative coupling of carboxylic acids with formamides for the synthesis of α,β-unsaturated amides
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A novel and efficient protocol for the synthesis of α,β- unsaturated amides has been developed using catalytic amount of Cu(OAc) 2 and TBHP as an available oxidant. Oxidative coupling of various unsaturated carboxylic acids with N,N-disubstituted formamides was examined to furnish the desired products in good yields.
- Li, Huamin,Pan, Changduo,Cheng, Yixiang,Zhu, Chengjian
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supporting information
p. 6679 - 6681
(2013/11/19)
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- Oxygen and base-free oxidative heck reactions of arylboronic acids with olefins
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A mild and efficient protocol for palladium-catalyzed oxidative Heck reactions of arylboronic acids with both electron-rich and -deficient olefins is described. In contrast to the normal oxidative Heck coupling, this new method works in the absence of a base, oxygen, or other external oxidants. With a wide variety of substrates tolerated, the method broadens the scope of palladium-catalyzed coupling reactions. Copyright
- Ruan, Jiwu,Li, Xinming,Saidi, Ourida,Xiao, Jianliang
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p. 2424 - 2425
(2008/09/18)
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- Mizoroki-Heck type arylation of alkenes using aroyl chlorides under base-free conditions
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The Mizoroki-Heck type arylation of alkenes with aroyl chlorides accompanied by decarbonylation efficiently proceeds in the presence of a palladium catalyst system, PdCl2(PhCN)2/(PhCH 2)Bu3NCl, even without adding any base. The products can be isolated by a very simple procedure.
- Sugihara, Toru,Satoh, Tetsuya,Miura, Masahiro
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p. 8269 - 8271
(2007/10/03)
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