- Process for making diaryl pyridines useful as cox-2 inhibitors
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The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
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Page column 17-18
(2010/01/31)
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- Preparation of 1,2,3,3-tetrachloropropene
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The dehydrochlorination of 1,1,2,3,3-pentachloropropane to produce 1,2,3,3-tetrachloropropene is conducted using aqueous alkali metal hydroxide in the substantial absence of added ethanol. The 1,2,3,3-tetrachloropropene is recovered from the reaction mixture in the substantial absence of added ether. The preferred methods of recovery are steam distillation and flash distillation.
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