cas 345627-80-7, N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide | Articles data ｜lookchem

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345627-80-7

Articles about 345627-80-7Total 3 be found

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CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY
The present invention relates to CDK inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The compounds of the invention may further act as HDAC inhibitors.
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(2009/04/25)

N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl] -4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent
N-Acyl-2-aminothiazoles with nonaromatic acyl side chains containing a basic amine were found to be potent, selective inhibitors of CDK2/cycE which exhibit antitumor activity in mice. In particular, compound 21 {N-[5-[[[5-(1,1-dimethylethyl)-2- oxazolyl]m
Misra, Raj N.,Xiao, Hai-Yun,Kim, Kyoung S.,Lu, Songfeng,Han, Wen-Ching,Barbosa, Stephanie A.,Hunt, John T.,Rawlins, David B.,Shan, Weifang,Ahmed, Syed Z.,Qian, Ligang,Chen, Bang-Chi,Zhao, Rulin,Bednarz, Mark S.,Kellar, Kristen A.,Mulheron, Janet G.,Batorsky, Roberta,Roongta, Urvashi,Kamath, Amrita,Marathe, Punit,Ranadive, Sunanda A.,Sack, John S.,Tokarski, John S.,Pavletich, Nikola P.,Lee, Francis Y. F.,Webster, Kevin R.,Kimball, S. David
p. 1719 - 1728
(2007/10/03)

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
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(2008/06/13)

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Chemical Properties

Melting Point: 171-173 °C
Density: 1.288 g/cm³
Solubility:DMSO (Slightly), Methanol (Slightly)
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index: 1.606
PKA: 7.33±0.70(Predicted)
PSA: 133.59000
LogP: 4.06080

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