- Surface-Specific Cleavage of a Cationic Carbonate-Functionalized Vesicular Surfactant
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The cationic, p-nitrophenyl carbonate functionalized 1,2 -dipalmitoylglyceryl surfactant 2 was synthesized.Vesicles created at pH 3.9 from this surfactant gave rapid partial p-nitrophenol release at pH 7.9, attributed to site-specific hydrolysis of exoves
- Moss, Robert A.,Bhattacharya, Santanu,Scrimin, Paolo,Swarup, Shanti
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- A METHOD FOR MODIFICATION OF PEPTIDES IMMOBILIZED ON A SOLID SUPPORT BY TRACELESS REDUCTIVELY CLEAVABLE LINKER MOLECULES
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The present invention relates to a method for modifying and purifying peptides comprising an immobilizing step, a modification step and a releasing step. In the immobilizing step, a crude linker-tagged peptide L-P is coupled to a solid support yielding an immobilized linker-tagged peptide S-L-P. Subsequently, the immobilized linker-tagged peptide S-L-P is modified with one or more organic molecules yielding an immobilized linker-tagged peptide S-L-mP. Finally, the modified peptide is released via a reduced intermediate RI. The linker molecule is a compound of formula 1, X-Tbb-Vaa-U-Y-Z (1), which can be coupled to a purification resin via the moiety X and to a peptide via the moiety Y under the release of the leaving group Z. T is an optional spacer moiety and V is an optional electron withdrawing moiety. U is an aryl or 5- or 6-membered heteroaryl moiety bound to at least one electron withdrawing moiety V, W or E. The linker is stable under acidic conditions and releases the peptide upon addition of a reducing agent.
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Page/Page column 55; 56
(2021/02/12)
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- A CONVENIENT METHOD OF ESTERIFICATION OF FATTY ACIDS. PREPARATION OF ALKYL ESTERS, STEROL ESTERS, WAX ESTERS AND TRIACYLGLYCEROLS
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A quick and mild, one-pot method of esterification of fatty acids with pripary, secondary and tertiary alcohols as well as with fatty alcohols, sterols and glycerol is proposed via the acyl bromides formed in situ.
- Saroja, M.,Kaimal, T. N. B.
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p. 1423 - 1430
(2007/10/02)
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