Chemically Stable, Lipophilic Prodrugs of Phosphoramide Mustard as Potential Anticancer Agents
Benzyl phosphoramide mustard (3), 2,4-difluorobenzyl phosphoramide mustard (4), and methyl phosphoramide mustard (5) were examined as lipophilic, chemically stable prodrugs of phosphoramide mustard (2).These phosphorodiamidic esters are designed to underg
Kwon, Chul-Hoon,Moon, Ki-Young,Baturay, Nesrine,Shirota, Frances N.
p. 588 - 592
(2007/10/02)
Synthesis, hydrolytic reactivity, and anticancer evaluation of N-and O-triorganosilylated compounds as new types of potential prodrugs
N- and O-Triorganosilylated compounds related to various anticancer agents were synthesized for evaluation as potential anticancer prodrugs. 1H-NMR and UV kinetic measurements of hydrolytic desilylation were used to correlate relative rates of structural unmasking with steric bulk about the silicon reaction center. The tert-butyldimethylsilyl ester of chlorambucil and a number of O-triorganosilylated carbamate derivatives of nor-nitrogen mustard showed significant activity against P-388 lymphocytic leukemia in mice.
Chiu,Chang,Ozkan,Zon,Fichter,Phillips
p. 542 - 551
(2007/10/02)
31P NMR kinetic studies of the intra- and intermolecular alkylation chemistry of phosphoramide mustard and cognate N-phosphorylated derivatives of N,N-bis(2-chloroethyl)amine
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Engle,Zon,Egan
p. 1347 - 1357
(2007/10/02)
SYNTHESIS OF N-PHOSPHORYLATED DERIVATIVES OF NITROGEN MUSTARDS WITH
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FRIEDMAN,BOGER,GRUBLIAUSKAS,SOMMER
p. 50 - 58
(2007/10/04)
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