- In Vitro and in Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas
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A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. The structure-activity relat
- Ottavi, Samantha,Scarry, Sarah M.,Mosior, John,Ling, Yan,Roberts, Julia,Singh, Amrita,Zhang, David,Goullieux, Laurent,Roubert, Christine,Bacqué, Eric,Lagiakos, H. Rachel,Vendome, Jeremie,Moraca, Francesca,Li, Kelin,Perkowski, Andrew J.,Ramesh, Remya,Bowler, Matthew M.,Tracy, William,Feher, Victoria A.,Sacchettini, James C.,Gold, Ben S.,Nathan, Carl F.,Aubé, Jeffrey
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p. 1996 - 2022
(2022/01/31)
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- Preparation method of 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine
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The invention discloses a preparation method of 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine, which comprises the following steps: by using ethylamine and cyanamide as initial raw materials, generating N-ethylguanidine sulfate under the action of concentrated sulfuric acid, reacting with 2-n-butyl ethyl acetoacetate under the action of sodium hydroxide for 1-4 hours, and carrying out after-treatment to obtain 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine. According to the method, cheap and easily available ethylamine and cyanamide are used as initial raw materials, the method is green and environment-friendly, isomers are separated by using a preparative chromatography technology, the yield and purity of the product are relatively high, and the method has a wide industrial application prospect.
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Paragraph 0032-0033; 0035-0036; 0038-0039; 0041-0042; 0044
(2021/04/21)
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