- PROCESSES FOR PRODUCTION OF INDOLE COMPOUNDS
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There is provided a process for producing an indole compound. A process for producing an indole compound of formula (2) (R2=H) characterized by using an acylating agent and a base together when 2-nitrobenzyl compound of formula (1) is reduced with a metal and an acid; a process for producing an indole compound of formula (2) (R2=halogen) characterized by reacting the indole compound of formula (2) (R2=H) with a hydrogen halide acid and a sulfoxide compound; and a process for producing a sulfamoyl triazole compound comprising reacting the indole compound of formula (2) directly with 3-chlorosulfonyl-1-(N,N-dimethylsulfamoyl)-1,2,4-triazole in the presence of a phase transfer catalyst and a base.
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- PROCESSES FOR PRODUCTION OF INDOLE COMPOUNDS
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[PROBLEMS] To provide processes for the production of indole compounds. [MEANS FOR SOLVING PROBLEMS] A process for the production of indole compounds represented by the general formula (2)(wherein R2 is H) by reducing a 2-nitrobenzylcarbonyl compound represented by the general formula (1) with a metal and an acid, characterized in that the reduction is carried out in the presence of an acylating agent and a base; a process for the production of indole compounds represented by the general formula (2) (wherein R2 is halogeno), characterized by reacting an indole compound represented by the general formula (2) (wherein R2 is H) with a hydrohalic acid and a sulfoxide; and a process for the production of sulfamoyltriazoles by reacting an indole compound represented by the general formula (2) (wherein R2 is halogeno) directly with 1-(N,N-dimethylsulfamoyl)-3-chlorosulfonyl-1,2,4-tri- azole in the presence of a phase transfer catalyst and a base.
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Page/Page column 19-20; 21-22
(2008/06/13)
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