- Photochemical reactivity of trifluoromethyl aromatic amines: The example of 3,5-diamino-trifluoromethyl-benzene (3,5-DABTF)
-
This work presents the application of an on-line photoreactor to the detection of 3,5-diamino-trifluoromethyl-benzene (3,5-DABTF) in aqueous solutions. When irradiated at 310 nm, this compound is defluorinated to 3,5-diaminobenzoic acid by a nucleophilic substitution of the fluoride by water. Concomitantly, defluorination intermediates polymerize through amide bonds to give dark-colored compounds. We take advantage of the photocatalyzed defluorination and the subsequent decrease in pH to develop an original and specific photoreactor. Continuous recording of pH and temperature in the outlet of the reactor by a dual electrode gives us an opportunity to optimize the system. In the photoreactor, 3,5-DABTF is immediately and totally transformed as attested by the rapid drop of the flowing solution pH from 6.2 to 3.2 and the chromatographic analysis of the outgoing solutions. The detection remains effective from 1 to 1000 parts per million.
- Chaignon, Philippe,Cortial, Sylvie,Guerineau, Vincent,Adeline, Marie-Therese,Giannotti, Charles,Fan, Gerard,Ouazzani, Jamal
-
-
Read Online
- Method for synthesizing 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl) aniline
-
The invention relates to a method for synthesizing 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl) aniline, which comprises the following steps: 1, by using 3,5-diaminobenzotrifluoride as a raw material, carrying out protection to obtain a mono-substituted product and an intermediate byproduct; and 2, carrying out a cyclization reaction on the mono-substituted product, and carrying out deprotection to obtain the 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl) aniline. The synthesis process is safe and reliable, and has the advantages of low cost, easy control of reaction, simple post-treatment, economy, environmental protection and the like.
- -
-
Paragraph 0029-0031
(2020/10/14)
-