- Novel process for synthesizing high-steric-hindrance bromobenzene
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The invention relates to a novel process for synthesizing high-steric-hindrance bromobenzene. A preparing method of aryl bromide includes the steps of conducting reaction on aniline hydrobromide and inorganic nitrite in a two-phase or multi-phase system f
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Paragraph 0051-0056; 0065; 0066
(2019/01/23)
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- Preparation method of multi-substituted phenol
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The invention provides a preparation method of multi-substituted phenol. According to the preparation method, raw materials, namely alkyl ketone and alkene, are subjected to condensation-aromatizationunder action of a catalyst to obtain multi-substituted phenol. Compared with the prior art, the preparation method has the advantages that the raw materials are easy to obtain, the yield is high, cost is low since use of expensive metallic catalysts is avoided, and the preparation method is suitable for industrial production and the like.
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Paragraph 0037; 0038
(2018/07/30)
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- Three-component asymmetric catalytic ugi reaction - Concinnity from diversity by substrate-mediated catalyst assembly
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The first chiral catalyst for the three-component Ugi reaction was identified as a result of a screen of a large set of different BOROX catalysts. The BOROX catalysts were assembled in situ from a chiral biaryl ligand, an amine, water, BH3×SMe2, and an alcohol or phenol. The catalyst screen included 13 different ligands, 12 amines, and 47 alcohols or phenols. The optimal catalyst system (LAP 8-5-47) provided α-amino amides from an aldehyde, a secondary amine, and an isonitrile with excellent asymmetric induction. The catalytically active species is proposed to be an ion pair that consists of the chiral boroxinate anion and an iminium cation. Harmonious arrangement of parts: A screen of BOROX catalysts that were generated in situ from 13 different ligands and 47 alcohols led to the identification of an effective combination for the catalytic asymmetric three-component Ugi reaction. Experimental results suggest that the catalyst is a chiral polyborate anion, which then forms an ion pair with the iminium cation that is generated from aldehyde and secondary amine.
- Zhao, Wenjun,Huang, Li,Guan, Yong,Wulff, William D.
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p. 3436 - 3441
(2014/04/03)
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- Halide-free ethylation of phenol by multifunctional catalysis using phosphinite ligands
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The ortho-alkylation of phenols or aniline by catalytic C-H activation and multifunctional catalysis is described. The Royal Society of Chemistry 2006.
- Carrion, M. Carmen,Cole-Hamilton, David J.
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p. 4527 - 4529
(2008/09/18)
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- Catalytic ethylation of phenols
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Alkylation of phenol and cresols with ethanol in the presence of iron-aluminum catalyst was studied.
- Agaev,Shakhtakhtinskaya,Eminov,Guliev
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p. 651 - 653
(2007/10/03)
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