- Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution
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Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.
- Bobbio, Carla,Rausis, Thierry,Schlosser, Manfred
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p. 1903 - 1910
(2007/10/03)
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- ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES
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Compounds of the following formula (I) are effective antimicrobial agents.
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- FLUORINATIONS WITH POTASSIUM TETRAFLUOROCOBALTATE(III) PART VII. FURTHER INVESTIGATIONS ON THE FLUORINATION OF PYRIDINE
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The product from the fluorination of pyridine by KCoF4 at ca. 220 deg C contains eleven fluoropyridines, two fluoro-2-azahex-enes, three azahexadienes, and two fluoro-N-methylpyrrolidines, besides an azacyclohexa-1,3-diene.Four products were isolated from fluorination of pyridine by CoF3 at ca. 150 deg C, a 2-azahexene, two N-methylpyrrolidines, and 4H-nonafluoropiperidine.
- Coe, Paul L.,Holton, Andrew G.,Tatlow, John Colin
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p. 171 - 190
(2007/10/02)
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