Effective Synthesis and Modification of α-Cyclodextrin-Based [3]Rotaxanes Enabling Versatile Molecular Design
One-pot synthesis of various α-cyclodextrin-(α-CD-) based [3]rotaxanes in water and their structural modifications are discussed in detail. Pseudo[3]rotaxane was prepared from α-CD and α,ω-diaminododecane in water (above 100 g, quantitative yield in a 1 L
Akae, Yosuke,Sogawa, Hiromitsu,Takata, Toshikazu
supporting information
p. 3605 - 3613
(2019/06/17)
Specific inhibitors of puromycin-sensitive aminopeptidase with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton
Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.