Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)- methanes as N-type calcium channel blockers
Voltage activated calcium channel (VACC blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-typ
Schelkun, Robert M.,Yuen, Po-wai,Malone, Thomas C.,Rock, David M.,Stoehr, Sally,Szoke, Balazs,Tarczy-Hornoch, Katalin
Substituted phenols as novel calcium channel blockers
PCT No. PCT/US96/08064 Sec. 371 Date Jan. 23, 1998 Sec. 102(e) Date Jan. 23, 1998 PCT Filed Jul. 16, 1996 PCT Pub. No. WO97/05125 PCT Pub. Date Feb. 13, 1997The present invention relates to novel substituted phenols and derivatives thereof useful in the t
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(2008/06/13)
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