- A kind of aldosterone synthase modulators method for the preparation of intermediates
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The invention discloses a method for preparing an aldosterone synthase conditioning agent intermediate. The method comprises the following steps: implementing reaction on a reaction substrate under Boc protection with hydrogen chloride and ethanol for acetal protection, directly heating to remove Boc protection without separation, implementing N-methylation reaction so as to obtain an N-methylation product, and directly removing acetal protection without separation, thereby obtaining a target product. The method is high in route reaction conversion rate and high in product purity, the product quality can be effectively ensured, and workshop production can be achieved.
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- PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS
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The present invention relates to compounds of the general formula (I) wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.
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Page/Page column 149-150
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- SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
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The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes
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Page/Page column 34
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- 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
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The present invention is directed to a compound of Formula (XVI) wherein R, R2, R3, R4, R5, R6, R7 and n are as defined herein, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, a pharmaceutically acceptable prodrug thereof, or a pharmac
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Page/Page column 77
(2008/06/13)
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