- Asymmetric dearomatic diels-alder reactions of diverse heteroarenes via π-system activation
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An asymmetric dearomatic Diels-Alder protocol for various heteroarenes, such as benzofuran, benzothiophene, or even furan, has been developed via π-system activation. This method involves in situ generation of formal trienamine species embedding a heteroa
- Xiao, You-Cai,Yue, Cai-Zhen,Chen, Peng-Qiao,Chen, Ying-Chun
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supporting information
p. 3208 - 3211
(2014/07/08)
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- Development of rationally designed DNA N6 adenine methyltransferase inhibitors
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A series of bisubstrate inhibitors for DNA N6 adenine methyltransferase (Dam) have been synthesized by linking an amine analogue of S-adenosylmethionine to an aryl moiety designed to probe the binding pocket of the DNA adenine base. An initial structure-activity relationship study has identified substituents that increase inhibitor potency to the ~10 μM range and improve selectivity against the human cytosine methyltransferase Dnmt1.
- Hobley, Gerard,McKelvie, Jennifer C.,Harmer, Jenny E.,Howe, Jason,Oyston, Petra C.F.,Roach, Peter L.
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p. 3079 - 3082
(2012/06/17)
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- INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53
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The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1, R2, A and Z have
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Page/Page column 37
(2008/06/13)
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