- Process For Preparing Alkylalkanolamines
-
The present invention relates to a process for preparing alkylalkanolamines, comprising the reaction of a carbonyl-based compound with a hydroxylalkylamine, in the presence of hydrogen and a catalyst.
- -
-
Page/Page column 4-5
(2012/05/20)
-
- Selective Access to Secondary Amines by a Highly Controlled Reductive Mono-N-Alkylation of Primary Amines
-
A selective and direct access to secondary amines is reported by reductive mono-N-alkylation of primary amines in the presence of Ti(i-PrO)4 and NaBH4. Secondary amines are obtained exclusively from a set of carbonyl compounds and primary amines, demonstrating high chemoselectivity toward reductive mono-N-alkylation.
- Kumpaty, Hephzibah J.,Bhattacharyya, Sukanta,Rehr, Erik W.,Gonzalez, Amelia M.
-
p. 2206 - 2210
(2007/10/03)
-
- Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
-
This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.
- -
-
Page column 37
(2010/02/05)
-
- OXAZOLIDINES. 1. BASIC CATALYTIC DISPROPORTIONATION OF CYCLOHEXANOSPIRO-2-OXAZOLIDINES: SYNTHESIS OF N-SUBSTITUTED 4,5,6,7-TETRAHYDROINDOLES
-
It has been shown that the basic catalytic disproportionation of cyclohexanospiro-2-oxazolidines in the presence of potasium hydroxide or sodium methylate leads to N-substituted 4,5,6,7-tetrahydroindoles with a yield of up to 73percent.The influence of the character of substituents at the nitrogen atom of oxazolidine on the course of the reaction has been established.
- Kukharev, B.F.,Stankevich, V.K.,Kukhareva, V.A.
-
p. 437 - 439
(2007/10/02)
-
- Reductive Alkylation of β-Alkanolamines with Carbonyl Compounds and Sodium Borohydride
-
A synthesis of secondary alkylalkanolamines from primary alkanolamines in a rapid process in which overalkylation is virtually suppressed is described.The procedure combines the ease of formation of oxazolidines from alkanolamines with aldehydes or ketones in absolute ethanol and the lability of the newly formed C-O bond toward sodium borohydrode.The entire process is carried out in 15-35 min depending on the carbonyl substrate.
- Saavedra, Joseph E.
-
p. 2271 - 2273
(2007/10/02)
-