One-pot three steps cascade synthesis of novel isoandrographolide analogues and their cytotoxic activity
An efficient one-pot synthesis of novel andrographolide analogues is reported from a naturally occurring and abundant andrographolide isolated from aerial parts of Andrographis paniculata. Reactions in the one-pot proceed through a cascade epoxide ring op
New substituted C-19-andrographolide analogues with potent cytotoxic activities
Andrographolide, the major diterpenoid lactone from Andrographis paniculata, is toxic against cancer cells. In the present study, we investigated the structure-activity relationships (SARs) of 19 andrographolide analogues which were synthesized by modific
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents
Andrographolide 1, the cytotoxic agent of the plant Andrographis paniculata was subjected to semi-synthetic studies leading to the preparation 19 and a number of related novel analogues. Synthesis and structure-activity relationships are discussed. Androg