- Asymmetric Sulfoxidation Catalyzed by a Vanadium-Containing Bromoperoxidase
-
A vanadium-containing bromoperoxidase (VBrPO) from the alga Corallina officinalis has been shown to catalyze the stereoselective oxidation of some aromatic bicyclic sulfides to the corresponding (S)-sulfoxides in high (up to 91%) ee. Hydrogen peroxide was found to have a large effect on the catalyzed reaction, most likely due to an inhibition of VBrPO. High optical and chemical yields were found to be favored by a continuous slow addition of hydrogen peroxide to keep a low excess. The reaction gives no overoxidation to sulfone, and its stereochemistry is the opposite as compared to that previously found with the heme-containing chloroperoxidase (CPO) from Caldariomyces fumago.
- Andersson, Malin,Willetts, Andrew,Allenmark, Stig
-
-
Read Online
- THIENODIAZEPINE DERIVATIVES AND APPLICATION THEREOF
-
The present invention relates to a class of thienodiazepine derivatives and an application thereof in the preparation of a drug for the treatment of diseases associated with bromodomain and extra-terminal (BET) Bromodomain inhibitors. Specifically, the present invention relates to compounds represented by formulas (I) and (II), as well as pharmaceutically acceptable salts thereof.
- -
-
Paragraph 0172-0174
(2020/08/09)
-
- Semiconductor material and preparation methods and applications thereof
-
The invention discloses a semiconductor material and preparation methods and applications thereof. A molecular structure general formula of the material is one of the formulas shown in the description. The semiconductor material provided by the invention
- -
-
Paragraph 0113; 0115
(2019/11/29)
-
- Air-Stable Benzo[ c]thiophene Diimide n-Type π-Electron Core
-
In this paper, the molecular design of the first deep-lowest unoccupied molecular orbital (LUMO) level diimide π-electron core, benzo[c]thiophene diimide (BTDI), as a novel n-type organic semiconductor was determined. An original synthetic sequence was de
- Yu, Craig P.,Kimura, Ryoya,Kurosawa, Tadanori,Fukuzaki, Eiji,Watanabe, Tetsuya,Ishii, Hiroyuki,Kumagai, Shohei,Yano, Masafumi,Takeya, Jun,Okamoto, Toshihiro
-
p. 4448 - 4453
(2019/06/17)
-
- A green and sustainable method for the oxidation of 1,3-dihydrobenzo[c] thiophenes to sulfones using metalloporphyrin complexes
-
Two efficient methods are reported for the oxidation of 1,3-dihydrobenzo[c]thiophenes to sulfones in good to high yields using H 2O2 in the presence of catalytic amounts of porphyrin-based catalysts in ethanol or acetonitrile as solvents at room temperature. The presence of electron-donating or electron-withdrawing groups, in the benzene ring of 1,3-dihydrobenzo[c]thiophene, is well tolerated.
- Da Silva, Gustavo,Pires, Sónia M.G.,Silva, Vera L.M.,Sim?es, Mário M.Q.,Neves, M. Gra?a P.M.S.,Rebelo, Susana L.H.,Silva, Artur M.S.,Cavaleiro, José A.S.
-
-
- HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
-
Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
- -
-
Page/Page column 72
(2013/08/28)
-
- Benzo[c]thiophene-C60 diadduct: An electron acceptor for p-n junction organic solar cells harvesting visible to near-IR light
-
We synthesized a new 56-π-electron fullerene derivative through a Diels-Alder cycloaddition of benzo[c]thiophene that featured a relatively low temperature, closer to stoichiometric use of the diene, and easy product purification. The 56-π-electron benzo[c]thiophene diadduct (BTCDA) has a LUMO energy level of 0.09 to 0.18 eV higher than that of 58-π-electron fullerenes, and therefore, the BTCDA-based organic photovoltaic device exhibited a higher open-circuit voltage and power-conversion efficiency (PCE). When used with a binary-donor system, including visible-light-harvesting tetrabenzoporphyrin (BP) and near-IR-harvesting titanyl phthalocyanine (TiOPc), the device had a PCE that was 1.5-3 times higher (2.8 %) than that for devices with BP or TiOPc alone because the binary-donor device can utilize light between λ=350 and 950 nm. Copyright
- Zhen, Yonggang,Obata, Naoki,Matsuo, Yutaka,Nakamura, Eiichi
-
p. 2644 - 2649,6
(2020/09/02)
-
- Synthesis and optical properties of 1,1-binaphthyl-thiophene alternating copolymers with main chain chirality
-
A series of axially chiral 1,1-binaphthyl-thiophene copolymers were synthesized by Migita-Kosugi-Stille polycondensation and electrochemical polymerization. The polymers exhibit circular dichroism not only in the ultraviolet region but also in the visible region, both in solution and film states. Optical and electrochemical properties of the polymers are in good agreement with theoretical results obtained by density functional theory calculations. Although effective conjugation of the polymers was cleaved at the orthogonally oriented two naphthalene rings in the 1,1-binaphthyl unit, the electrochemically synthesized polymer film shows good electrochemical redox behavior with repeatable changes in optical absorption and circular dichroism. The changes in circular dichroism may reflect a change in the dihedral angle of the binaphthyl unit caused by reorientation of conjugated main chains between oxidized and neutral states. The Royal Society of Chemistry 2012.
- Kawabata, Kohsuke,Goto, Hiromasa
-
p. 23514 - 23524
(2013/02/25)
-
- Biotransformation of organic sulfides. Part 12. Conversion of heterocyclic sulfides to chiral sulfoxides by Helminthosporium sp. NRRL 4671 and Mortierella isabellina ATCC 42613
-
The enantioselective oxidation of a series of heterocyclic prochiral sulfides to chiral sulfoxides has been examined using the fungal biocatalysts Helminthosporium species NRRL 4671 and Mortierella isabellina ATCC 42613. Methylthiofuranyl and -thiophenyl
- Holland, Herbert L.,Turner, Carl D.,Andreana, Peter R.,Nguyen, Doan
-
p. 463 - 471
(2007/10/03)
-
- Structure and Reactivity of Isoannulated Heterocyclic Systems with 4n-? and (4n + 2)-? Electrons, XVIII. - Benzothiophenes with Symmetric Structure: Modified and Optimized Preparations by the S-Oxide Route
-
Benzothiophenes (15) with symmetric structure have been prepared efficiently from 1,3-dihydrobenzothiophene 2-oxides (9) by reaction with aluminium oxide, by O-acylation with trifluoroacetic anhydride, or O-alkylation with methyl trifluoromethanesulfonate.The aromatization of the S-oxides 9 is achieved by O-functionalization, subsequent elimination, and consecutive deprotonation.
- Kreher, Richard P.,Kalischko, Juergen
-
p. 645 - 654
(2007/10/02)
-
- CHEMICAL REPERCUSSIONS OF ORBITAL INTERACTIONS THROUGH BOND AND THROUGH SPACE. EFFECT OF REMOTE SUBSTITUENTS ON THE ADDITION OF NITRENES TO BICYCLIC OLEFINS
-
The reactivity of a series of bicyclic olefins with nitrenes is profoundly influenced by the nature of remote functional groups.There is a marked lack of reactivity for reactions with carboethoxynitrene as compared to phthalimidonitrene which is distinctly nucleophilic in character.An explanation for the reluctance to form aziridines is offered in terms of orbital interactions between the distant groups and the olefinic bond, making the latter remarkably electron deficient as evidenced by UV-photoelectron spectroscopy.Because of the complexity of the spectra, identification of the Ip associated with the reactive ?-centre was made by recourse to ab initio configuration interaction calculations for key members of the series.
- Aitken, R. Alan,Gosney, Ian,Farries, Hugh,Palmer, Michael H.,Simpson, Isobel,et. al.
-
p. 1329 - 1346
(2007/10/02)
-