- EFFICIENT SYNTHESIS OF ACETOXYFIMBROLIDES AND BECKERELIDES ANALOGS
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An efficient synthesis of acetoxyfimbrolides and beckerelides analogs has been developed via peracid oxidation of 2-methyl-4-(1-acetoxybutyl)furan as the key synthetic step.Antimicrobial activity of the products has also been tested.
- Kotsuki, Hiyoshizo,Monden, Mitsugu,Ochi, Masamitsu
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- Synthesis of substituted furoates from acrylates and aldehydes by Pd(OAc)2/HPMoV/CeCl3/O2 system
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(Chemical Equation Presented) A new synthetic method of substituted furoates from acrylates and aldehydes was developed by Pd-(OAc)2 combined with molybdovanadophosphoric acid and Lewis acid under atmospheric dioxygen. The reaction was found to proceed through the palladium-catalyzed acetalization of acrylates with methanol followed by the reaction of the resulting acetals with aldehydes.
- Tamaso, Ken-Ichi,Hatamoto, Yuji,Obora, Yasushi,Sakaguchi, Satoshi,Ishii, Yasutaka
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p. 8820 - 8823
(2008/03/12)
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- Process for the preparation of furan compounds
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A carbonyl compound represented by following Formula (1): wherein R1 represents hydrogen atom or an organic group; and R2 represents hydrogen atom or an organic group having a carbon atom at a bonding site with the carbonyl group in Formula (1), wherein R1 and R2 may be combined to form a ring with adjacent two carbon atoms, or an equivalent thereof is reacted with an unsaturated compound represented by following Formula (2): wherein each of R3, R4, and R5 represents hydrogen atom, a halogen atom, hydroxyl group, or an organic group and wherein R3 and R4 may be combined to form a ring with adjacent two carbon atoms, or a precursor thereof, to yield a furan compound represented by following Formula (3): wherein R3′ represents R3, R5 or hydrogen atom; and R1, R2, R3, R4, are R5 are as defined above.
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Page/Page column 7
(2008/06/13)
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